TY - JOUR
T1 - Absent audiovisual integration elicited by peripheral stimuli in Parkinson's disease
AU - Ren, Yanna
AU - Suzuki, Keisuke
AU - Yang, Weiping
AU - Ren, Yanling
AU - Wu, Fengxia
AU - Yang, Jiajia
AU - Takahashi, Satoshi
AU - Ejima, Yoshimichi
AU - Wu, Jinglong
AU - Hirata, Koichi
N1 - Funding Information:
0is study was supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant no. 16K18052; the National Natural Science Foundation of China (61473043; 61727807; 31600882; 31700973); the Beijing Municipal Science and Technology Commission (Z161100002616020); the Humanity and Social Science Youth Foundation of the Education Bureau of Hubei Province of China (16Q030, Weiping Yang); and the Humanity and Social Science Youth Foundation of the Ministry of Education of China (16YJC190025).
Publisher Copyright:
© 2018 Yanna Ren et al.
PY - 2018
Y1 - 2018
N2 - The basal ganglia, which have been shown to be a significant multisensory hub, are disordered in Parkinson's disease (PD). This study was to investigate the audiovisual integration of peripheral stimuli in PD patients with/without sleep disturbances. Thirty-six age-matched normal controls (NC) and 30 PD patients were recruited for an auditory/visual discrimination experiment. The mean response times for each participant were analyzed using repeated measures ANOVA and race model. The results showed that the response to all stimuli was significantly delayed for PD compared to NC (all p<0.01). The response to audiovisual stimuli was significantly faster than that to unimodal stimuli in both NC and PD (p<0.001). Additionally, audiovisual integration was absent in PD; however, it did occur in NC. Further analysis showed that there was no significant audiovisual integration in PD with/without cognitive impairment or in PD with/without sleep disturbances. Furthermore, audiovisual facilitation was not associated with Hoehn and Yahr stage, disease duration, or the presence of sleep disturbances (all p>0.05). The current results showed that audiovisual multisensory integration for peripheral stimuli is absent in PD regardless of sleep disturbances and further suggested the abnormal audiovisual integration might be a potential early manifestation of PD.
AB - The basal ganglia, which have been shown to be a significant multisensory hub, are disordered in Parkinson's disease (PD). This study was to investigate the audiovisual integration of peripheral stimuli in PD patients with/without sleep disturbances. Thirty-six age-matched normal controls (NC) and 30 PD patients were recruited for an auditory/visual discrimination experiment. The mean response times for each participant were analyzed using repeated measures ANOVA and race model. The results showed that the response to all stimuli was significantly delayed for PD compared to NC (all p<0.01). The response to audiovisual stimuli was significantly faster than that to unimodal stimuli in both NC and PD (p<0.001). Additionally, audiovisual integration was absent in PD; however, it did occur in NC. Further analysis showed that there was no significant audiovisual integration in PD with/without cognitive impairment or in PD with/without sleep disturbances. Furthermore, audiovisual facilitation was not associated with Hoehn and Yahr stage, disease duration, or the presence of sleep disturbances (all p>0.05). The current results showed that audiovisual multisensory integration for peripheral stimuli is absent in PD regardless of sleep disturbances and further suggested the abnormal audiovisual integration might be a potential early manifestation of PD.
UR - http://www.scopus.com/inward/record.url?scp=85046036618&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85046036618&partnerID=8YFLogxK
U2 - 10.1155/2018/1648017
DO - 10.1155/2018/1648017
M3 - Article
AN - SCOPUS:85046036618
SN - 2090-8083
VL - 2018
JO - Parkinson's Disease
JF - Parkinson's Disease
M1 - 1648017
ER -
