Absent skeletal uptake of 99mTc-hydroxymethylene diphosphonate in the presence of AL-type amyloidosis associated with multiple myeloma

Tomoaki Sasaki; Atsutaka Okizaki; Koji Takahashi; Masayuki Mineta; Kenichi Nagasawa; Yasuomi Fujimoto; Kyuhei Kohda; Tamio Aburano

doi:10.1007/s11604-011-0596-4

Absent skeletal uptake of ^99mTc-hydroxymethylene diphosphonate in the presence of AL-type amyloidosis associated with multiple myeloma

Tomoaki Sasaki, Atsutaka Okizaki, Koji Takahashi, Masayuki Mineta, Kenichi Nagasawa, Yasuomi Fujimoto, Kyuhei Kohda, Tamio Aburano

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A 66-year-old woman with congestive heart failure suspected to have multiple myeloma underwent bone scintigraphy. The bone scintigraphy using technetium- 99m hydroxymethylene-diphosphonate showed the following interesting fi ndings: absent skeletal uptake; increased gastrointestinal, myocardial, and soft tissue uptake; migration of radionuclide to bilateral pleural effusions. Histopathological examination revealed that the patient suffered from AL-type amyloidosis associated with multiple myeloma. Extraosseous uptake is often observed on bone scintigraphy in amyloidosis patients, but in many cases skeletal uptake is preserved. The simultaneous presentation of these fi ndings is rare.

Original language	English
Pages (from-to)	595-597
Number of pages	3
Journal	Japanese Journal of Radiology
Volume	29
Issue number	8
DOIs	https://doi.org/10.1007/s11604-011-0596-4
Publication status	Published - Oct 2011
Externally published	Yes

Keywords

AL-type amyloidosis
Multiple myeloma
Tc-99m HMDP

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1007/s11604-011-0596-4

Cite this

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title = "Absent skeletal uptake of 99mTc-hydroxymethylene diphosphonate in the presence of AL-type amyloidosis associated with multiple myeloma",

abstract = "A 66-year-old woman with congestive heart failure suspected to have multiple myeloma underwent bone scintigraphy. The bone scintigraphy using technetium- 99m hydroxymethylene-diphosphonate showed the following interesting fi ndings: absent skeletal uptake; increased gastrointestinal, myocardial, and soft tissue uptake; migration of radionuclide to bilateral pleural effusions. Histopathological examination revealed that the patient suffered from AL-type amyloidosis associated with multiple myeloma. Extraosseous uptake is often observed on bone scintigraphy in amyloidosis patients, but in many cases skeletal uptake is preserved. The simultaneous presentation of these fi ndings is rare.",

keywords = "AL-type amyloidosis, Multiple myeloma, Tc-99m HMDP",

author = "Tomoaki Sasaki and Atsutaka Okizaki and Koji Takahashi and Masayuki Mineta and Kenichi Nagasawa and Yasuomi Fujimoto and Kyuhei Kohda and Tamio Aburano",

year = "2011",

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doi = "10.1007/s11604-011-0596-4",

language = "English",

volume = "29",

pages = "595--597",

journal = "Japanese Journal of Radiology",

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T1 - Absent skeletal uptake of 99mTc-hydroxymethylene diphosphonate in the presence of AL-type amyloidosis associated with multiple myeloma

AU - Sasaki, Tomoaki

AU - Okizaki, Atsutaka

AU - Takahashi, Koji

AU - Mineta, Masayuki

AU - Nagasawa, Kenichi

AU - Fujimoto, Yasuomi

AU - Kohda, Kyuhei

AU - Aburano, Tamio

PY - 2011/10

Y1 - 2011/10

N2 - A 66-year-old woman with congestive heart failure suspected to have multiple myeloma underwent bone scintigraphy. The bone scintigraphy using technetium- 99m hydroxymethylene-diphosphonate showed the following interesting fi ndings: absent skeletal uptake; increased gastrointestinal, myocardial, and soft tissue uptake; migration of radionuclide to bilateral pleural effusions. Histopathological examination revealed that the patient suffered from AL-type amyloidosis associated with multiple myeloma. Extraosseous uptake is often observed on bone scintigraphy in amyloidosis patients, but in many cases skeletal uptake is preserved. The simultaneous presentation of these fi ndings is rare.

AB - A 66-year-old woman with congestive heart failure suspected to have multiple myeloma underwent bone scintigraphy. The bone scintigraphy using technetium- 99m hydroxymethylene-diphosphonate showed the following interesting fi ndings: absent skeletal uptake; increased gastrointestinal, myocardial, and soft tissue uptake; migration of radionuclide to bilateral pleural effusions. Histopathological examination revealed that the patient suffered from AL-type amyloidosis associated with multiple myeloma. Extraosseous uptake is often observed on bone scintigraphy in amyloidosis patients, but in many cases skeletal uptake is preserved. The simultaneous presentation of these fi ndings is rare.

KW - AL-type amyloidosis

KW - Multiple myeloma

KW - Tc-99m HMDP

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