Absolute configuration of amphidinin A

Takahiro Iwai; Takaaki Kubota; Jun'Ichi Kobayashi

doi:10.1021/np5003065

Absolute configuration of amphidinin A

Takahiro Iwai, Takaaki Kubota, Jun'Ichi Kobayashi

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

The absolute configurations at six stereogenic centers in amphidinin A (1), a cytotoxic linear polyketide isolated from a symbiotic marine dinoflagellate, Amphidinium sp., were elucidated to be 2R, 4R, 6S, 9R 11R, and 12S by the combination of J-based configuration analysis, modified Mosher's method, and density-functional theory calculations.

Original language	English
Pages (from-to)	1541-1544
Number of pages	4
Journal	Journal of Natural Products
Volume	77
Issue number	6
DOIs	https://doi.org/10.1021/np5003065
Publication status	Published - Jun 27 2014
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/np5003065

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Absolute configuration of amphidinin A

Abstract

ASJC Scopus subject areas

UN SDGs

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