Absolute stereochemistry of amphidinolide C

Takaaki Kubota; Masashi Tsuda; Jun'ichi Kobayashi

doi:10.1021/ol015741z

Absolute stereochemistry of amphidinolide C

Takaaki Kubota, Masashi Tsuda, Jun'ichi Kobayashi

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Abstract

(equation presented) The absolute configurations at 12 chiral centers in amphidinolide C (1), a potent cytotoxic 25-membered macrolide isolated from a marine dinoflagellate Amphidinium sp., were determined to be 3S, 4R, 6R, 7R, BR, 12R, 13S, 16S, 20R, 23R, 24R, and 29S by combination of NMR analyses, degradation experiments, and synthesis of the C-1-C-7 segment.

Original language	English
Pages (from-to)	1363-1366
Number of pages	4
Journal	Organic Letters
Volume	3
Issue number	9
DOIs	https://doi.org/10.1021/ol015741z
Publication status	Published - May 3 2001
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/ol015741z

Cite this

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abstract = "(equation presented) The absolute configurations at 12 chiral centers in amphidinolide C (1), a potent cytotoxic 25-membered macrolide isolated from a marine dinoflagellate Amphidinium sp., were determined to be 3S, 4R, 6R, 7R, BR, 12R, 13S, 16S, 20R, 23R, 24R, and 29S by combination of NMR analyses, degradation experiments, and synthesis of the C-1-C-7 segment.",

author = "Takaaki Kubota and Masashi Tsuda and Jun'ichi Kobayashi",

year = "2001",

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AU - Tsuda, Masashi

AU - Kobayashi, Jun'ichi

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AB - (equation presented) The absolute configurations at 12 chiral centers in amphidinolide C (1), a potent cytotoxic 25-membered macrolide isolated from a marine dinoflagellate Amphidinium sp., were determined to be 3S, 4R, 6R, 7R, BR, 12R, 13S, 16S, 20R, 23R, 24R, and 29S by combination of NMR analyses, degradation experiments, and synthesis of the C-1-C-7 segment.

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Absolute stereochemistry of amphidinolide C

Abstract

ASJC Scopus subject areas

UN SDGs

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