Abundant retention and release of connective tissue growth factor (CTGF/CCN2) by platelets

Satoshi Kubota, Kazumi Kawata, Takeshi Yanagita, Hideyuki Doi, Takashi Kitoh, Masaharu Takigawa

Research output: Contribution to journalArticlepeer-review

72 Citations (Scopus)


Wound healing and tissue regeneration are usually initiated by coagulation followed by fibrous tissue formation. In the present study, we discovered, an abundance of connective tissue growth factor (CTGF/CCN2) in human platelets, which was released along with the coagulation process. The CTGF/CCN2 content in platelets was 10-fold higher than that in arterial tissue. Furthermore, the CTGF/CCN2 content in a single platelet was computed to be more than 20-fold higher than that of any other growth factor reported. Considering that CTGF/CCN2 promotes angiogenesis, cartilage regeneration, fibrosis and platelet adhesion, it may be now regarded as one of tlie major functional components of platelets.

Original languageEnglish
Pages (from-to)279-282
Number of pages4
JournalJournal of biochemistry
Issue number3
Publication statusPublished - Sept 2004


  • CCN2
  • CTGF
  • Platelet
  • Tissue regeneration
  • Wound healing

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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