Acute anti-inflammatory markers ITIH4 and AHSG in mice brain of a novel Alzheimer's disease model

Xiaowen Shi; Yasuyuki Ohta; Xia Liu; Jingwei Shang; Ryuta Morihara; Yumiko Nakano; Tian Feng; Yong Huang; Kota Sato; Mami Takemoto; Nozomi Hishikawa; Toru Yamashita; Koji Abe

doi:10.3233/JAD-181218

Acute anti-inflammatory markers ITIH4 and AHSG in mice brain of a novel Alzheimer's disease model

Xiaowen Shi, Yasuyuki Ohta, Xia Liu, Jingwei Shang, Ryuta Morihara, Yumiko Nakano, Tian Feng, Yong Huang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Koji Abe

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is the most common dementia and a progressive neurodegenerative disorder aggravated by chronic hypoperfusion (HP). Since numerous evidence suggests that inflammation is related with AD pathology, we investigated the expression change of two anti-inflammatory markers, inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) and alpha-2-HS-glycoprotein (AHSG), in a novelADmodel (APP23) with HP at 12 month of age. As compared with wild type (WT, n = 10), immunohistochemical analysis showed a higher ITIH4 and a lower AHSG expressions in the cerebral cortex, hippocampus, and thalamus of the APP23 +HP group (n = 12) than the simple APP23 (n = 10) group (∗p < 0.05 and ∗ ∗p < 0.01 versus WT; #p < 0.05 and ##p < 0.01 versus APP23). The present study provides an upregulation of anti-inflammatory ITIH4 and a downregulation of pro-inflammatory TNF-dependent AHSG in a novel AD plus HP mice model.

Original language	English
Pages (from-to)	1667-1675
Number of pages	9
Journal	Journal of Alzheimer's Disease
Volume	68
Issue number	4
DOIs	https://doi.org/10.3233/JAD-181218
Publication status	Published - 2019

Keywords

AHSG
APP23 mice
Alzheimer's disease
Hypoperfusion
ITIH4
Inflammation

ASJC Scopus subject areas

Neuroscience(all)
Clinical Psychology
Geriatrics and Gerontology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3233/JAD-181218

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@article{8ba44d1af91a4d9fb27aad43dcceca29,

title = "Acute anti-inflammatory markers ITIH4 and AHSG in mice brain of a novel Alzheimer's disease model",

abstract = "Alzheimer's disease (AD) is the most common dementia and a progressive neurodegenerative disorder aggravated by chronic hypoperfusion (HP). Since numerous evidence suggests that inflammation is related with AD pathology, we investigated the expression change of two anti-inflammatory markers, inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) and alpha-2-HS-glycoprotein (AHSG), in a novelADmodel (APP23) with HP at 12 month of age. As compared with wild type (WT, n = 10), immunohistochemical analysis showed a higher ITIH4 and a lower AHSG expressions in the cerebral cortex, hippocampus, and thalamus of the APP23 +HP group (n = 12) than the simple APP23 (n = 10) group (∗p < 0.05 and ∗ ∗p < 0.01 versus WT; #p < 0.05 and ##p < 0.01 versus APP23). The present study provides an upregulation of anti-inflammatory ITIH4 and a downregulation of pro-inflammatory TNF-dependent AHSG in a novel AD plus HP mice model.",

keywords = "AHSG, APP23 mice, Alzheimer's disease, Hypoperfusion, ITIH4, Inflammation",

author = "Xiaowen Shi and Yasuyuki Ohta and Xia Liu and Jingwei Shang and Ryuta Morihara and Yumiko Nakano and Tian Feng and Yong Huang and Kota Sato and Mami Takemoto and Nozomi Hishikawa and Toru Yamashita and Koji Abe",

note = "Funding Information: This work was partly supported by a Grant-in-Aid for Scientific Research (B) 17H0419619, (C) 15K0931607, 17H0419619 and 17K1082709, and by Grants-in-Aid from the Research Committees (Kaji R, Toba K, and Tsuji S) from Japan Agency for Medical Research and development (AMED) 7211700176, 7211700180 and 7211700095. X. S. would like to thank Otsuka Toshimi Scholarship Foundation for a scholarship support (18-235). Publisher Copyright: {\textcopyright} 2019 - IOS Press and the authors. All rights reserved.",

year = "2019",

doi = "10.3233/JAD-181218",

language = "English",

volume = "68",

pages = "1667--1675",

journal = "Journal of Alzheimer's Disease",

issn = "1387-2877",

publisher = "IOS Press",

number = "4",

}

TY - JOUR

T1 - Acute anti-inflammatory markers ITIH4 and AHSG in mice brain of a novel Alzheimer's disease model

AU - Shi, Xiaowen

AU - Ohta, Yasuyuki

AU - Liu, Xia

AU - Shang, Jingwei

AU - Morihara, Ryuta

AU - Nakano, Yumiko

AU - Feng, Tian

AU - Huang, Yong

AU - Sato, Kota

AU - Takemoto, Mami

AU - Hishikawa, Nozomi

AU - Yamashita, Toru

AU - Abe, Koji

N1 - Funding Information: This work was partly supported by a Grant-in-Aid for Scientific Research (B) 17H0419619, (C) 15K0931607, 17H0419619 and 17K1082709, and by Grants-in-Aid from the Research Committees (Kaji R, Toba K, and Tsuji S) from Japan Agency for Medical Research and development (AMED) 7211700176, 7211700180 and 7211700095. X. S. would like to thank Otsuka Toshimi Scholarship Foundation for a scholarship support (18-235). Publisher Copyright: © 2019 - IOS Press and the authors. All rights reserved.

PY - 2019

Y1 - 2019

N2 - Alzheimer's disease (AD) is the most common dementia and a progressive neurodegenerative disorder aggravated by chronic hypoperfusion (HP). Since numerous evidence suggests that inflammation is related with AD pathology, we investigated the expression change of two anti-inflammatory markers, inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) and alpha-2-HS-glycoprotein (AHSG), in a novelADmodel (APP23) with HP at 12 month of age. As compared with wild type (WT, n = 10), immunohistochemical analysis showed a higher ITIH4 and a lower AHSG expressions in the cerebral cortex, hippocampus, and thalamus of the APP23 +HP group (n = 12) than the simple APP23 (n = 10) group (∗p < 0.05 and ∗ ∗p < 0.01 versus WT; #p < 0.05 and ##p < 0.01 versus APP23). The present study provides an upregulation of anti-inflammatory ITIH4 and a downregulation of pro-inflammatory TNF-dependent AHSG in a novel AD plus HP mice model.

AB - Alzheimer's disease (AD) is the most common dementia and a progressive neurodegenerative disorder aggravated by chronic hypoperfusion (HP). Since numerous evidence suggests that inflammation is related with AD pathology, we investigated the expression change of two anti-inflammatory markers, inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) and alpha-2-HS-glycoprotein (AHSG), in a novelADmodel (APP23) with HP at 12 month of age. As compared with wild type (WT, n = 10), immunohistochemical analysis showed a higher ITIH4 and a lower AHSG expressions in the cerebral cortex, hippocampus, and thalamus of the APP23 +HP group (n = 12) than the simple APP23 (n = 10) group (∗p < 0.05 and ∗ ∗p < 0.01 versus WT; #p < 0.05 and ##p < 0.01 versus APP23). The present study provides an upregulation of anti-inflammatory ITIH4 and a downregulation of pro-inflammatory TNF-dependent AHSG in a novel AD plus HP mice model.

KW - AHSG

KW - APP23 mice

KW - Alzheimer's disease

KW - Hypoperfusion

KW - ITIH4

KW - Inflammation

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UR - http://www.scopus.com/inward/citedby.url?scp=85064884139&partnerID=8YFLogxK

U2 - 10.3233/JAD-181218

DO - 10.3233/JAD-181218

M3 - Article

C2 - 30958362

AN - SCOPUS:85064884139

SN - 1387-2877

VL - 68

SP - 1667

EP - 1675

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

IS - 4

ER -

Acute anti-inflammatory markers ITIH4 and AHSG in mice brain of a novel Alzheimer's disease model

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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