Abstract
Add-on polytherapy with antidepressant agents was reviewed in 42 inpatients with major depression diagnosed according to the ICD-10 criteria. Twenty-eight (67.7%) patients were treated with two or more antidepressants. The most frequent combination consisted of a tricyclic antidepressant and a non-tricyclic antidepressant. Nineteen (67.8%) patients of the polytherapy group were treated with a dosage equivalent to 150 mg/day of tricyclic antidepressant. Clinically, not every patient with major depression can tolerate the adverse side effects induced by an effective dose of a single tricyclic antidepressant. From this viewpoint, add-on polytherapy with antidepressants could be one of the treatment options, especially for such intolerant patients.
| Original language | English |
|---|---|
| Pages (from-to) | 557-562 |
| Number of pages | 6 |
| Journal | Psychiatry and clinical neurosciences |
| Volume | 53 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Oct 1 1999 |
Keywords
- Antidepressants
- Effective dose
- Inpatient
- Major depression
- Polytherapy
ASJC Scopus subject areas
- Neuroscience(all)
- Neurology
- Clinical Neurology
- Psychiatry and Mental health
