TY - JOUR
T1 - Additional translocation (8;21)(q22;q22) in a patient with philadelphia- positive chronic myelogenous leukaemia in the blastic phase
AU - Kojima, Kensuke
AU - Yasukawa, Masaki
AU - Ishimaru, Fumihiko
AU - Dansako, Hiromichi
AU - Matsuo, Yoshinobu
AU - Kimura, Yukio
AU - Nawa, Yuichiro
AU - Hara, Masamichi
AU - Harada, Mine
PY - 1999
Y1 - 1999
N2 - We report a case of Philadelphia-positive chronic myelogenous leukaemia in blastic phase with the additional translocation (8;21)(q22;q22), which is frequent in acute myeloid leukaemia but not in chronic myelogenous leukaemia. The t(8;21) was not detected in the chronic phase, and was the only additional chromosomal anomaly in the blastic clone. Reverse transcription- polymerase chain reaction revealed the AML1/ETO fusion transcript in the cells of blastic phase but not in those of chronic phase. Regarding t(9;22), the breakpoint on chromosome 22 occurred in the μ-BCR region of the BCR gene, resulting in hybrid BCR/ABL mRNA with an e19a2 junction. Our findings provided molecular evidence that t(8;21) can occur as an additional genetic change in Philadelphia-positive chronic myelogenous leukaemia.
AB - We report a case of Philadelphia-positive chronic myelogenous leukaemia in blastic phase with the additional translocation (8;21)(q22;q22), which is frequent in acute myeloid leukaemia but not in chronic myelogenous leukaemia. The t(8;21) was not detected in the chronic phase, and was the only additional chromosomal anomaly in the blastic clone. Reverse transcription- polymerase chain reaction revealed the AML1/ETO fusion transcript in the cells of blastic phase but not in those of chronic phase. Regarding t(9;22), the breakpoint on chromosome 22 occurred in the μ-BCR region of the BCR gene, resulting in hybrid BCR/ABL mRNA with an e19a2 junction. Our findings provided molecular evidence that t(8;21) can occur as an additional genetic change in Philadelphia-positive chronic myelogenous leukaemia.
KW - Chronic myelogenous leukaemia
KW - E19a2 type BCR/ABL rearrangement
KW - Translocation (8;21)
KW - Translocation (9;22)
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U2 - 10.1046/j.1365-2141.1999.01588.x
DO - 10.1046/j.1365-2141.1999.01588.x
M3 - Article
C2 - 10468864
AN - SCOPUS:0032827064
SN - 0007-1048
VL - 106
SP - 720
EP - 722
JO - British Journal of Haematology
JF - British Journal of Haematology
IS - 3
ER -