Adenosine A2A-receptor stimulation inhibits lipopolysaccharide- induced interleukin-18 production in monocytes

Hideo Kohka Takahashi; Toru Kanke; Keyue Liu; Tadashi Yoshino; Toshiaki Sendo; Noriaki Tanaka; Masahiro Nishibori

doi:10.1254/jphs.SC0070101

Adenosine A2A-receptor stimulation inhibits lipopolysaccharide- induced interleukin-18 production in monocytes

Hideo Kohka Takahashi, Toru Kanke, Keyue Liu, Tadashi Yoshino, Toshiaki Sendo, Noriaki Tanaka, Masahiro Nishibori

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Adenosine inhibited interleukin (IL)-18 production in lipopolysaccharide (LPS)-stimulated monocytes. The action of adenosine was antagonized by an adenosine A₂A-receptor (A2AR) antagonist and was mimicked by an A2AR agonist, suggesting that the stimulation of A2AR may be involved in the actions of adenosine. On the other hand, the stimulation of A1R and A3R inhibited the actions of A2AR stimulation, whereas the stimulation of A2BR had no effect on them. Activation of A2AR is known to increase cyclic adenosine monophosphate (cAMP) levels and to activate protein kinase A (PKA). A PKA inhibitor prevented the actions of A2AR stimulation, indicating that the action mechanism of A2AR stimulation may be via the activation of the cAMP/PKA pathway.

Original language	English
Pages (from-to)	183-186
Number of pages	4
Journal	Journal of Pharmacological Sciences
Volume	104
Issue number	2
DOIs	https://doi.org/10.1254/jphs.SC0070101
Publication status	Published - 2007

Keywords

Adenosine
Interleukin-18
Monocyte

ASJC Scopus subject areas

Molecular Medicine
Pharmacology

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10.1254/jphs.SC0070101

Cite this

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title = "Adenosine A2A-receptor stimulation inhibits lipopolysaccharide- induced interleukin-18 production in monocytes",

abstract = "Adenosine inhibited interleukin (IL)-18 production in lipopolysaccharide (LPS)-stimulated monocytes. The action of adenosine was antagonized by an adenosine A2A-receptor (A2AR) antagonist and was mimicked by an A2AR agonist, suggesting that the stimulation of A2AR may be involved in the actions of adenosine. On the other hand, the stimulation of A1R and A3R inhibited the actions of A2AR stimulation, whereas the stimulation of A2BR had no effect on them. Activation of A2AR is known to increase cyclic adenosine monophosphate (cAMP) levels and to activate protein kinase A (PKA). A PKA inhibitor prevented the actions of A2AR stimulation, indicating that the action mechanism of A2AR stimulation may be via the activation of the cAMP/PKA pathway.",

keywords = "Adenosine, Interleukin-18, Monocyte",

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T1 - Adenosine A2A-receptor stimulation inhibits lipopolysaccharide- induced interleukin-18 production in monocytes

AU - Takahashi, Hideo Kohka

AU - Kanke, Toru

AU - Liu, Keyue

AU - Yoshino, Tadashi

AU - Sendo, Toshiaki

AU - Tanaka, Noriaki

AU - Nishibori, Masahiro

PY - 2007

Y1 - 2007

N2 - Adenosine inhibited interleukin (IL)-18 production in lipopolysaccharide (LPS)-stimulated monocytes. The action of adenosine was antagonized by an adenosine A2A-receptor (A2AR) antagonist and was mimicked by an A2AR agonist, suggesting that the stimulation of A2AR may be involved in the actions of adenosine. On the other hand, the stimulation of A1R and A3R inhibited the actions of A2AR stimulation, whereas the stimulation of A2BR had no effect on them. Activation of A2AR is known to increase cyclic adenosine monophosphate (cAMP) levels and to activate protein kinase A (PKA). A PKA inhibitor prevented the actions of A2AR stimulation, indicating that the action mechanism of A2AR stimulation may be via the activation of the cAMP/PKA pathway.

AB - Adenosine inhibited interleukin (IL)-18 production in lipopolysaccharide (LPS)-stimulated monocytes. The action of adenosine was antagonized by an adenosine A2A-receptor (A2AR) antagonist and was mimicked by an A2AR agonist, suggesting that the stimulation of A2AR may be involved in the actions of adenosine. On the other hand, the stimulation of A1R and A3R inhibited the actions of A2AR stimulation, whereas the stimulation of A2BR had no effect on them. Activation of A2AR is known to increase cyclic adenosine monophosphate (cAMP) levels and to activate protein kinase A (PKA). A PKA inhibitor prevented the actions of A2AR stimulation, indicating that the action mechanism of A2AR stimulation may be via the activation of the cAMP/PKA pathway.

KW - Adenosine

KW - Interleukin-18

KW - Monocyte

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Adenosine A2A-receptor stimulation inhibits lipopolysaccharide- induced interleukin-18 production in monocytes

Abstract

Keywords

ASJC Scopus subject areas

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