TY - JOUR
T1 - Adrenergic stimulation - Released histamine taken-up in adrenergic nerves induces endothelium-dependent vasodilation in rat mesenteric resistance arteries
AU - Haruki, Yuto
AU - Takatori, Shingo
AU - Hattori, Sayo
AU - Zamami, Yoshito
AU - Koyama, Toshihiro
AU - Tangsucharit, Panot
AU - Kawasaki, Hiromu
PY - 2011
Y1 - 2011
N2 - The present study investigated whether histamine was taken up by perivascular adrenergic nerves and released by periarterial nerve stimulation (PNS) to induce vascular responses. In rat mesenteric vascular beds treated with capsaicin to eliminate calcitonin gene - related peptide (CGRP)ergic vasodilation and with active tone, PNS (1-4 Hz) induced only adrenergic nerve - mediated vasoconstriction. Histamine treatment for 20 min induced PNS-induced vasoconstriction followed by vasodilation without affecting CGRP-induced vasodilation. Chlorpheniramine, guanethidine, combination of histamine and desipramine, and endothelium-removal abolished PNS-induced vasodilation in histamine-treated preparations. These results suggest that histamine taken up by and released from adrenergic nerves by PNS causes endothelium-dependent vasodilation in rat mesenteric arteries.
AB - The present study investigated whether histamine was taken up by perivascular adrenergic nerves and released by periarterial nerve stimulation (PNS) to induce vascular responses. In rat mesenteric vascular beds treated with capsaicin to eliminate calcitonin gene - related peptide (CGRP)ergic vasodilation and with active tone, PNS (1-4 Hz) induced only adrenergic nerve - mediated vasoconstriction. Histamine treatment for 20 min induced PNS-induced vasoconstriction followed by vasodilation without affecting CGRP-induced vasodilation. Chlorpheniramine, guanethidine, combination of histamine and desipramine, and endothelium-removal abolished PNS-induced vasodilation in histamine-treated preparations. These results suggest that histamine taken up by and released from adrenergic nerves by PNS causes endothelium-dependent vasodilation in rat mesenteric arteries.
KW - Histamine
KW - Perivascular adrenergic nerve
KW - Rat mesenteric artery
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U2 - 10.1254/jphs.12012SC
DO - 10.1254/jphs.12012SC
M3 - Article
C2 - 22510969
AN - SCOPUS:84867206575
SN - 1347-8613
VL - 118
SP - 537
EP - 542
JO - Journal of Pharmacological Sciences
JF - Journal of Pharmacological Sciences
IS - 4
ER -