Adrenomedullin 2 and 5

Maho Ogoshi

doi:10.1016/B978-0-12-820649-2.00109-1

Adrenomedullin 2 and 5

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

AM2 and AM5 are novel members of the calcitonin gene-related peptide (CGRP) family and consist of a single intramolecular ring structure and an amidated C-terminus, which are common to this family of peptides. AM2 and AM5 are both conserved in vertebrates, from fish to mammals, although AM5 is mutated or deleted in some species, including humans, mice, and rats. AM2 is expressed ubiquitously in the body, and exerts various effects similar to those of AM. Hypotension is currently likely to be the main function of AM2. Mammalian AM5 is expressed in the spleen and thymus and causes hypotension by peripheral administration, but its major biological function is not fully clarified yet. The specific receptors for AM2 and AM5 are still unknown.

Original language	English
Title of host publication	Handbook of Hormones
Subtitle of host publication	Comparative Endocrinology for Basic and Clinical Research
Publisher	Elsevier
Pages	421-423
Number of pages	3
ISBN (Electronic)	9780128206492
DOIs	https://doi.org/10.1016/B978-0-12-820649-2.00109-1
Publication status	Published - Jan 1 2021

Keywords

Hypotension
Multiple function and novel peptides

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1016/B978-0-12-820649-2.00109-1

Cite this

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title = "Adrenomedullin 2 and 5",

abstract = "AM2 and AM5 are novel members of the calcitonin gene-related peptide (CGRP) family and consist of a single intramolecular ring structure and an amidated C-terminus, which are common to this family of peptides. AM2 and AM5 are both conserved in vertebrates, from fish to mammals, although AM5 is mutated or deleted in some species, including humans, mice, and rats. AM2 is expressed ubiquitously in the body, and exerts various effects similar to those of AM. Hypotension is currently likely to be the main function of AM2. Mammalian AM5 is expressed in the spleen and thymus and causes hypotension by peripheral administration, but its major biological function is not fully clarified yet. The specific receptors for AM2 and AM5 are still unknown.",

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N2 - AM2 and AM5 are novel members of the calcitonin gene-related peptide (CGRP) family and consist of a single intramolecular ring structure and an amidated C-terminus, which are common to this family of peptides. AM2 and AM5 are both conserved in vertebrates, from fish to mammals, although AM5 is mutated or deleted in some species, including humans, mice, and rats. AM2 is expressed ubiquitously in the body, and exerts various effects similar to those of AM. Hypotension is currently likely to be the main function of AM2. Mammalian AM5 is expressed in the spleen and thymus and causes hypotension by peripheral administration, but its major biological function is not fully clarified yet. The specific receptors for AM2 and AM5 are still unknown.

AB - AM2 and AM5 are novel members of the calcitonin gene-related peptide (CGRP) family and consist of a single intramolecular ring structure and an amidated C-terminus, which are common to this family of peptides. AM2 and AM5 are both conserved in vertebrates, from fish to mammals, although AM5 is mutated or deleted in some species, including humans, mice, and rats. AM2 is expressed ubiquitously in the body, and exerts various effects similar to those of AM. Hypotension is currently likely to be the main function of AM2. Mammalian AM5 is expressed in the spleen and thymus and causes hypotension by peripheral administration, but its major biological function is not fully clarified yet. The specific receptors for AM2 and AM5 are still unknown.

KW - Hypotension

KW - Multiple function and novel peptides

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M3 - Chapter

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SP - 421

EP - 423

BT - Handbook of Hormones

PB - Elsevier

ER -

Adrenomedullin 2 and 5

Abstract

Keywords

ASJC Scopus subject areas

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