AM2 and AM5 are novel members of the calcitonin gene-related peptide (CGRP) family and consist of a single intramolecular ring structure and amidated C-terminus, which are common to this family of peptides. AM2 and AM5 are both conserved in vertebrates, from fish to mammals, although AM5 is mutated or deleted in some species, including humans, mice, and rats. AM2 is expressed ubiquitously in the body, and exerts various effects which are similar to those of AM. Hypotension is currently likely to be the main function of AM2. Mammalian AM5 is expressed in the spleen and thymus and causes hypotension by peripheral administration, but its major biological function is not fully clarified yet. The specific receptors for AM2 and AM5 are still unknown.

Original languageEnglish
Title of host publicationHandbook of Hormones
Subtitle of host publicationComparative Endocrinology for Basic and Clinical Research
ISBN (Electronic)9780128010280
ISBN (Print)9780128010679
Publication statusPublished - Jan 1 2015


  • hypotension
  • multiple function
  • novel peptides

ASJC Scopus subject areas

  • General Medicine


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