Aeromonas sobria hemolysin causes diarrhea by increasing secretion of HCO3-

Akira Takahashi; Masayuki Nakano; Keinosuke Okamoto; Yoshio Fujii; Kazuaki Mawatari; Nagakatsu Harada; Yutaka Nakaya

doi:10.1111/j.1574-6968.2006.00204.x

Aeromonas sobria hemolysin causes diarrhea by increasing secretion of HCO₃^-

Akira Takahashi, Masayuki Nakano, Keinosuke Okamoto, Yoshio Fujii, Kazuaki Mawatari, Nagakatsu Harada, Yutaka Nakaya

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Aeromonas sobria hemolysin (ASH) is one of the major virulence factors produced by A. sobria, a causative agent of diarrhea in humans. We investigated the effects of ASH on anion transport in human colonic epithelial cells. ASH increased short circuit currents across the intestinal epithelia, which were suppressed by anion channel antagonists, such as carbonic anhydrase inhibitors, and by the removal of external HCO₃^-. Iliac fluid accumulation was also inhibited by carbonic anhydrase inhibitors. The results suggest that ASH activates HCO₃^- secretion, whose level correlates with the severity of diarrhea.

Original language	English
Pages (from-to)	92-95
Number of pages	4
Journal	FEMS Microbiology Letters
Volume	258
Issue number	1
DOIs	https://doi.org/10.1111/j.1574-6968.2006.00204.x
Publication status	Published - May 2006

Keywords

Aeromonas sobria hemolysin (ASH)
Cystic fibrosis transmembrane conductance regulator (CFTR)
HCO secretion
Short circuit currents (I)

ASJC Scopus subject areas

Microbiology
Molecular Biology
Genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/j.1574-6968.2006.00204.x

Cite this

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abstract = "Aeromonas sobria hemolysin (ASH) is one of the major virulence factors produced by A. sobria, a causative agent of diarrhea in humans. We investigated the effects of ASH on anion transport in human colonic epithelial cells. ASH increased short circuit currents across the intestinal epithelia, which were suppressed by anion channel antagonists, such as carbonic anhydrase inhibitors, and by the removal of external HCO3-. Iliac fluid accumulation was also inhibited by carbonic anhydrase inhibitors. The results suggest that ASH activates HCO3- secretion, whose level correlates with the severity of diarrhea.",

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AU - Takahashi, Akira

AU - Nakano, Masayuki

AU - Okamoto, Keinosuke

AU - Fujii, Yoshio

AU - Mawatari, Kazuaki

AU - Harada, Nagakatsu

AU - Nakaya, Yutaka

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AB - Aeromonas sobria hemolysin (ASH) is one of the major virulence factors produced by A. sobria, a causative agent of diarrhea in humans. We investigated the effects of ASH on anion transport in human colonic epithelial cells. ASH increased short circuit currents across the intestinal epithelia, which were suppressed by anion channel antagonists, such as carbonic anhydrase inhibitors, and by the removal of external HCO3-. Iliac fluid accumulation was also inhibited by carbonic anhydrase inhibitors. The results suggest that ASH activates HCO3- secretion, whose level correlates with the severity of diarrhea.

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