Age-related analysis of the gut microbiome in a purebred dog colony

Keijiro Mizukami, Jumpei Uchiyama, Hirotaka Igarashi, Hironobu Murakami, Takafumi Osumi, Ayaka Shima, Genki Ishiahra, Tadahiro Nasukawa, Yumi Une, Masahiro Sakaguchi

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Dogs are model animals that can be used to study the gut microbiome. Although the gut microbiome is assumed to be closely related to aging, information pertaining to this relationship in dogs is limited. Here, we examined the association between the canine gut microbiome and age via a bacterial 16S rRNA gene amplicon sequence analysis in a colony of 43 Japanese purebred Shiba Inu dogs. We found that microbial diversity tended to decrease with aging. A differential abundance analysis showed an association of a single specific microbe with aging. The age-related coabundance network analysis showed that two microbial network modules were positively and negatively associated with aging, respectively. These results suggest that the dog gut microbiome is likely to vary with aging.

Original languageEnglish
Article numberfnz095
JournalFEMS Microbiology Letters
Issue number8
Publication statusPublished - Apr 1 2019
Externally publishedYes


  • 16S rRNA gene amplicon sequencing
  • Aging
  • Dogs
  • Gut microbiome
  • Purebred colony
  • Shiba Inu

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics


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