Age-Related Changes in Cerebrospinal Fluid y-Aminobutyric Acid Concentration

Haruhiko Takayama, Norio Ogawa, Mitsutoshi Yamamoto, Masato Asanuma, Hiroshi Hirata, Zensuke Ota

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


The purpose of this study was to clarify the effect of aging on brain y-aminobutyric acid metabolism. We measured the cerebrospinal fluid y-aminobutyric acid concentration in subjects of various ages, including healthy volunteers and patients without neurological or psychiatric disease. The cerebrospinal fluid y-aminobutyric acid concentration was determined by radiolabelled receptor assay using [3H]γ-aminobutyric acid. Cerebrospinal fluid y-aminobutyric acid was significantly higher in the control group (20s and 30s) than in the groups of subjects in their 50s, 60s, 70s and 80s. There was a significant negative correlation between cerebrospinal y-aminobutyric acid concentration and age (p < 0.01). These data suggest that dysfunction of brain y-aminobutyric acid metabolism increases with age, and that the various symptoms caused by abnormal y-aminobutyric acid metabolism in the brain are therefore more likely to appear in elderly people.

Original languageEnglish
Pages (from-to)271-274
Number of pages4
JournalClinical Chemistry and Laboratory Medicine
Issue number5
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical


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