Age-related decrease in calcitonin gene-related peptide mRNA in the dorsal root ganglia of spontaneously hypertensive rats

N. Yamaga; H. Kawasaki; K. Inaizumi; M. Shimizu; A. Nakamura; Y. Kurosaki

doi:10.1254/jjp.86.448

Age-related decrease in calcitonin gene-related peptide mRNA in the dorsal root ganglia of spontaneously hypertensive rats

N. Yamaga, H. Kawasaki, K. Inaizumi, M. Shimizu, A. Nakamura, Y. Kurosaki

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Age-related changes in levels of calcitonin gene-related peptide (CGRP) mRNA of the dorsal root ganglia was studied in 8-, 12- and 15-week-old spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar Kyoto rats (WKY). CGRP mRNA levels in SHR but not in WKY decreased with age. The contents of CGRP-like immunoreactivities in the atrium and mesenteric artery of 15-week-old SHR were greater than those in age-matched WKY. These results suggest that the outflow of CGRP-containing nerves from the spinal cord and CGRP release from CGRP nerve terminals decreases in SHR.

Original language	English
Pages (from-to)	448-450
Number of pages	3
Journal	Japanese Journal of Pharmacology
Volume	86
Issue number	4
DOIs	https://doi.org/10.1254/jjp.86.448
Publication status	Published - 2001

Keywords

Calcitonin gene-related peptide (CGRP) mRNA
Mesenteric arterial CGRP content
Spontaneously hypertensive rat

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1254/jjp.86.448

Cite this

@article{38df4792f192499781b2792d6869fac8,

title = "Age-related decrease in calcitonin gene-related peptide mRNA in the dorsal root ganglia of spontaneously hypertensive rats",

abstract = "Age-related changes in levels of calcitonin gene-related peptide (CGRP) mRNA of the dorsal root ganglia was studied in 8-, 12- and 15-week-old spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar Kyoto rats (WKY). CGRP mRNA levels in SHR but not in WKY decreased with age. The contents of CGRP-like immunoreactivities in the atrium and mesenteric artery of 15-week-old SHR were greater than those in age-matched WKY. These results suggest that the outflow of CGRP-containing nerves from the spinal cord and CGRP release from CGRP nerve terminals decreases in SHR.",

keywords = "Calcitonin gene-related peptide (CGRP) mRNA, Mesenteric arterial CGRP content, Spontaneously hypertensive rat",

author = "N. Yamaga and H. Kawasaki and K. Inaizumi and M. Shimizu and A. Nakamura and Y. Kurosaki",

year = "2001",

doi = "10.1254/jjp.86.448",

language = "English",

volume = "86",

pages = "448--450",

journal = "Japanese Journal of Pharmacology",

issn = "0021-5198",

publisher = "Japanese Pharmacological Society",

number = "4",

}

TY - JOUR

T1 - Age-related decrease in calcitonin gene-related peptide mRNA in the dorsal root ganglia of spontaneously hypertensive rats

AU - Yamaga, N.

AU - Kawasaki, H.

AU - Inaizumi, K.

AU - Shimizu, M.

AU - Nakamura, A.

AU - Kurosaki, Y.

PY - 2001

Y1 - 2001

N2 - Age-related changes in levels of calcitonin gene-related peptide (CGRP) mRNA of the dorsal root ganglia was studied in 8-, 12- and 15-week-old spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar Kyoto rats (WKY). CGRP mRNA levels in SHR but not in WKY decreased with age. The contents of CGRP-like immunoreactivities in the atrium and mesenteric artery of 15-week-old SHR were greater than those in age-matched WKY. These results suggest that the outflow of CGRP-containing nerves from the spinal cord and CGRP release from CGRP nerve terminals decreases in SHR.

AB - Age-related changes in levels of calcitonin gene-related peptide (CGRP) mRNA of the dorsal root ganglia was studied in 8-, 12- and 15-week-old spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar Kyoto rats (WKY). CGRP mRNA levels in SHR but not in WKY decreased with age. The contents of CGRP-like immunoreactivities in the atrium and mesenteric artery of 15-week-old SHR were greater than those in age-matched WKY. These results suggest that the outflow of CGRP-containing nerves from the spinal cord and CGRP release from CGRP nerve terminals decreases in SHR.

KW - Calcitonin gene-related peptide (CGRP) mRNA

KW - Mesenteric arterial CGRP content

KW - Spontaneously hypertensive rat

UR - http://www.scopus.com/inward/record.url?scp=0034819278&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034819278&partnerID=8YFLogxK

U2 - 10.1254/jjp.86.448

DO - 10.1254/jjp.86.448

M3 - Article

C2 - 11569619

AN - SCOPUS:0034819278

SN - 0021-5198

VL - 86

SP - 448

EP - 450

JO - Japanese Journal of Pharmacology

JF - Japanese Journal of Pharmacology

IS - 4

ER -

Age-related decrease in calcitonin gene-related peptide mRNA in the dorsal root ganglia of spontaneously hypertensive rats

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this