Aggregated chromosomes transfer in human oocytes

Junko Otsuki, Yasushi Nagai, Tadashi Sankai

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Germinal-vesicle (GV) transfer, spindle-chromosome complex transfer in metaphase-II oocytes and two pronuclei transfer have been evaluated as possible treatments for patients who have mitochondrial diseases. However, GV transfers often lead to heteroplasmy while the other two methods are frequently associated with aneuploidy. The present study used a new method based on the transfer of aggregated chromosomes, which occurs in human oocytes, before the metaphase spindle is established.

Original languageEnglish
Pages (from-to)401-404
Number of pages4
JournalReproductive BioMedicine Online
Issue number3
Publication statusPublished - Mar 2014
Externally publishedYes


  • aggregated chromosomes
  • aneuploidy
  • heteroplasmy
  • microinjection
  • mitochondrial disease
  • nuclear transfer

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology
  • Developmental Biology


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