TY - JOUR
T1 - Airway complications have a greater impact on the outcomes of living-donor lobar lung transplantation recipients than cadaveric lung transplantation recipients
AU - Sugimoto, Seiichiro
AU - Yamane, Masaomi
AU - Otani, Shinji
AU - Kurosaki, Takeshi
AU - Okahara, Shuji
AU - Hikasa, Yukiko
AU - Toyooka, Shinichi
AU - Kobayashi, Motomu
AU - Oto, Takahiro
N1 - Funding Information:
Acknowledgements This work was supported by a Grant-in-Aid for Scientific Research, Grant no. 15K10256, from the Japan Society for the Promotion of Science.
Publisher Copyright:
© 2018, Springer Nature Singapore Pte Ltd.
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Purpose: Airway complications (ACs) after living-donor lobar lung transplantation (LDLLT) could have different features from those after cadaveric lung transplantation (CLT). We conducted this study to compare the characteristics of ACs after LDLLT vs. those after CLT and investigate their impact on outcomes. Methods: We reviewed, retrospectively, data on 163 recipients of lung transplantation, including 83 recipients of LDLLT and 80 recipients of CLT. Results: The incidence of ACs did not differ between LDLLT and CLT. The initial type of AC after LDLLT was limited to stenosis in all eight patients, whereas that after CLT consisted of stenosis in three patients and necrosis in ten patients (p = 0.0034). ACs after LDLLT necessitated significantly earlier initiation of treatment than those after CLT (p = 0.032). The overall survival rate of LDLLT recipients with an AC was significantly lower than that of those without an AC (p = 0.030), whereas the overall survival rate was comparable between CLT recipients with and those without ACs (p = 0.25). Conclusion: ACs after LDLLT, limited to bronchial stenosis, require significantly earlier treatment and have a greater adverse impact on survival than ACs after CLT.
AB - Purpose: Airway complications (ACs) after living-donor lobar lung transplantation (LDLLT) could have different features from those after cadaveric lung transplantation (CLT). We conducted this study to compare the characteristics of ACs after LDLLT vs. those after CLT and investigate their impact on outcomes. Methods: We reviewed, retrospectively, data on 163 recipients of lung transplantation, including 83 recipients of LDLLT and 80 recipients of CLT. Results: The incidence of ACs did not differ between LDLLT and CLT. The initial type of AC after LDLLT was limited to stenosis in all eight patients, whereas that after CLT consisted of stenosis in three patients and necrosis in ten patients (p = 0.0034). ACs after LDLLT necessitated significantly earlier initiation of treatment than those after CLT (p = 0.032). The overall survival rate of LDLLT recipients with an AC was significantly lower than that of those without an AC (p = 0.030), whereas the overall survival rate was comparable between CLT recipients with and those without ACs (p = 0.25). Conclusion: ACs after LDLLT, limited to bronchial stenosis, require significantly earlier treatment and have a greater adverse impact on survival than ACs after CLT.
KW - Airway complication
KW - Cadaveric lung transplantation
KW - Living-donor lobar lung transplantation
KW - Lung transplantation
UR - http://www.scopus.com/inward/record.url?scp=85051750336&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85051750336&partnerID=8YFLogxK
U2 - 10.1007/s00595-018-1663-6
DO - 10.1007/s00595-018-1663-6
M3 - Article
C2 - 29680912
AN - SCOPUS:85051750336
SN - 0941-1291
VL - 48
SP - 848
EP - 855
JO - Japanese Journal of Surgery
JF - Japanese Journal of Surgery
IS - 9
ER -