Allogeneic peripheral blood stem celll transplantation for the treatment of chronic active Epstein-Barr virus infection

N. Fujii; K. Takenaka; A. Hiraki; Y. Maeda; K. Ikeda; K. Shinagawa; A. Ashiba; M. Munemasa; K. Sunami; Y. Hiramatsu; F. Ishimaru; K. Niiya; T. Yoshino; M. Harada

doi:10.1038/sj.bmt.1702600

Allogeneic peripheral blood stem celll transplantation for the treatment of chronic active Epstein-Barr virus infection

N. Fujii, K. Takenaka, A. Hiraki, Y. Maeda, K. Ikeda, K. Shinagawa, A. Ashiba, M. Munemasa, K. Sunami, Y. Hiramatsu, F. Ishimaru, K. Niiya, T. Yoshino, M. Harada

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The prognosis of chronic active Epstein-Barr virus infection (CAEBV) is very poor. We describe a 24-year-old male with severe CAEBV who was treated with allogeneic peripheral blood stem cell transplantation (allo-PBSCT). On admission, EBER-1 in lymphocytes infiltrating the liver, EBV-DNA in peripheral blood mononuclear cells (PBMC) and monoclonal NK cell proliferation were confirmed. After unsuccessful chemotherapy, he received an allo-PBSCT from his HLA-identical sister. Although he died of pulmonary hemorrhage on day +19, EBV-DNA was undetectable by PCR in PBMC, and the post-mortem liver showed no EBER-1-positive lymphocytes. This experience suggests that EBV-positive lymphocytes in CAEBV may be eradicated by allo-PBSCT, thereby raising the possibility of a new treatment modality.

Original language	English
Pages (from-to)	805-808
Number of pages	4
Journal	Bone Marrow Transplantation
Volume	26
Issue number	7
DOIs	https://doi.org/10.1038/sj.bmt.1702600
Publication status	Published - 2000

Keywords

Allogeneic peripheral blood stem cell transplantation
Chronic active Epstein-Barr virus infection
EBV-specific CTL
Myeloablative conditioning regimen

ASJC Scopus subject areas

Hematology
Transplantation

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Fujii, N., Takenaka, K., Hiraki, A., Maeda, Y., Ikeda, K., Shinagawa, K., Ashiba, A., Munemasa, M., Sunami, K., Hiramatsu, Y., Ishimaru, F., Niiya, K., Yoshino, T., & Harada, M. (2000). Allogeneic peripheral blood stem celll transplantation for the treatment of chronic active Epstein-Barr virus infection. Bone Marrow Transplantation, 26(7), 805-808. https://doi.org/10.1038/sj.bmt.1702600

Fujii, N, Takenaka, K, Hiraki, A, Maeda, Y, Ikeda, K, Shinagawa, K, Ashiba, A, Munemasa, M, Sunami, K, Hiramatsu, Y, Ishimaru, F, Niiya, K, Yoshino, T & Harada, M 2000, 'Allogeneic peripheral blood stem celll transplantation for the treatment of chronic active Epstein-Barr virus infection', Bone Marrow Transplantation, vol. 26, no. 7, pp. 805-808. https://doi.org/10.1038/sj.bmt.1702600

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abstract = "The prognosis of chronic active Epstein-Barr virus infection (CAEBV) is very poor. We describe a 24-year-old male with severe CAEBV who was treated with allogeneic peripheral blood stem cell transplantation (allo-PBSCT). On admission, EBER-1 in lymphocytes infiltrating the liver, EBV-DNA in peripheral blood mononuclear cells (PBMC) and monoclonal NK cell proliferation were confirmed. After unsuccessful chemotherapy, he received an allo-PBSCT from his HLA-identical sister. Although he died of pulmonary hemorrhage on day +19, EBV-DNA was undetectable by PCR in PBMC, and the post-mortem liver showed no EBER-1-positive lymphocytes. This experience suggests that EBV-positive lymphocytes in CAEBV may be eradicated by allo-PBSCT, thereby raising the possibility of a new treatment modality.",

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author = "N. Fujii and K. Takenaka and A. Hiraki and Y. Maeda and K. Ikeda and K. Shinagawa and A. Ashiba and M. Munemasa and K. Sunami and Y. Hiramatsu and F. Ishimaru and K. Niiya and T. Yoshino and M. Harada",

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AU - Hiraki, A.

AU - Maeda, Y.

AU - Ikeda, K.

AU - Shinagawa, K.

AU - Ashiba, A.

AU - Munemasa, M.

AU - Sunami, K.

AU - Hiramatsu, Y.

AU - Ishimaru, F.

AU - Niiya, K.

AU - Yoshino, T.

AU - Harada, M.

PY - 2000

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AB - The prognosis of chronic active Epstein-Barr virus infection (CAEBV) is very poor. We describe a 24-year-old male with severe CAEBV who was treated with allogeneic peripheral blood stem cell transplantation (allo-PBSCT). On admission, EBER-1 in lymphocytes infiltrating the liver, EBV-DNA in peripheral blood mononuclear cells (PBMC) and monoclonal NK cell proliferation were confirmed. After unsuccessful chemotherapy, he received an allo-PBSCT from his HLA-identical sister. Although he died of pulmonary hemorrhage on day +19, EBV-DNA was undetectable by PCR in PBMC, and the post-mortem liver showed no EBER-1-positive lymphocytes. This experience suggests that EBV-positive lymphocytes in CAEBV may be eradicated by allo-PBSCT, thereby raising the possibility of a new treatment modality.

KW - Allogeneic peripheral blood stem cell transplantation

KW - Chronic active Epstein-Barr virus infection

KW - EBV-specific CTL

KW - Myeloablative conditioning regimen

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Allogeneic peripheral blood stem celll transplantation for the treatment of chronic active Epstein-Barr virus infection

Abstract

Keywords

ASJC Scopus subject areas

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