Alteration of parvalbumin expression and perineuronal nets formation in the cerebral cortex of aged mice

Hiroshi Ueno, Kazuki Fujii, Keizo Takao, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Aging is associated with decline in cognitive function, but the underlying mechanisms have not been elucidated. Normal activity of pyramidal cells and parvalbumin-expressing interneurons (PV neurons) is essential for cognitive function. PV neurons participate in the regulation of pyramidal-cell firing. Abnormal function of PV neurons may occur with aging. We analyzed the density and the percentage of PV neurons surrounded by perineuronal nets (PNNs) in the entire cortex of adult (3-month-old) and aged (24-month-old) mice. PNNs are extracellular matrix molecules that cover PV neurons and control synaptic plasticity. PV-neuron density decreased in some cortical areas of aged compared to adult mice. In particular, in the retrosplenial granular cortex (RSG) of aged mice, pyramidal cells expressed PV protein at high levels. This study suggests that the RSG of aged mice is in an abnormal activated state. RSG function abnormality may be part of the cognitive decline mechanism.

Original languageEnglish
Pages (from-to)31-42
Number of pages12
JournalMolecular and Cellular Neuroscience
Publication statusPublished - Mar 2019


  • Aging
  • Cerebral cortex
  • Mouse
  • Parvalbumin
  • Perineuronal nets
  • Retrosplenial cortex

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Cell Biology


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