Amphezonol A, a novel polyhydroxyl metabolite from marine dinoflagellate Amphidinium sp.

Takaaki Kubota; Yusuke Sakuma; Kazutaka Shimbo; Masashi Tsuda; Michiko Nakano; Yasuhiro Uozumi; Jun'ichi Kobayashi

doi:10.1016/j.tetlet.2006.04.094

Amphezonol A, a novel polyhydroxyl metabolite from marine dinoflagellate Amphidinium sp.

Takaaki Kubota, Yusuke Sakuma, Kazutaka Shimbo, Masashi Tsuda, Michiko Nakano, Yasuhiro Uozumi, Jun'ichi Kobayashi

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Amphezonol A (1), a novel polyhydroxyl linear carbon-chain metabolite, has been isolated from the cultured marine dinoflagellate Amphidinium sp., which was isolated from an Okinawan marine acoel flatworm Amphiscolops sp. The structure of 1 was elucidated by detailed analyses of 2D NMR spectra. Amphezonol A (1) possesses one tetrahydrofuran ring, two tetrahydropyran rings, and twenty-one hydroxyl groups on C₆₀-linear aliphatic chain with one exo-methylene and one methyl branch. Amphezonol A (1) exhibited a modest inhibitory activity against DNA polymerase α.

Original language	English
Pages (from-to)	4369-4371
Number of pages	3
Journal	Tetrahedron Letters
Volume	47
Issue number	26
DOIs	https://doi.org/10.1016/j.tetlet.2006.04.094
Publication status	Published - Jun 26 2006
Externally published	Yes

Keywords

Amphezonol A
Amphidinium sp.
Dinoflagellate
Polyhydroxyl metabolite

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tetlet.2006.04.094

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@article{398ef41af80f41cebec26cb08f036d55,

title = "Amphezonol A, a novel polyhydroxyl metabolite from marine dinoflagellate Amphidinium sp.",

abstract = "Amphezonol A (1), a novel polyhydroxyl linear carbon-chain metabolite, has been isolated from the cultured marine dinoflagellate Amphidinium sp., which was isolated from an Okinawan marine acoel flatworm Amphiscolops sp. The structure of 1 was elucidated by detailed analyses of 2D NMR spectra. Amphezonol A (1) possesses one tetrahydrofuran ring, two tetrahydropyran rings, and twenty-one hydroxyl groups on C60-linear aliphatic chain with one exo-methylene and one methyl branch. Amphezonol A (1) exhibited a modest inhibitory activity against DNA polymerase α.",

keywords = "Amphezonol A, Amphidinium sp., Dinoflagellate, Polyhydroxyl metabolite",

author = "Takaaki Kubota and Yusuke Sakuma and Kazutaka Shimbo and Masashi Tsuda and Michiko Nakano and Yasuhiro Uozumi and Jun'ichi Kobayashi",

note = "Funding Information: The authors thank Ms. S. Oka and Ms. M. Kiuchi, Center for Instrumental Analysis, Hokkaido University, for measurements of FABMS. This work was partly supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan.",

year = "2006",

month = jun,

day = "26",

doi = "10.1016/j.tetlet.2006.04.094",

language = "English",

volume = "47",

pages = "4369--4371",

journal = "Tetrahedron Letters",

issn = "0040-4039",

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TY - JOUR

T1 - Amphezonol A, a novel polyhydroxyl metabolite from marine dinoflagellate Amphidinium sp.

AU - Kubota, Takaaki

AU - Sakuma, Yusuke

AU - Shimbo, Kazutaka

AU - Tsuda, Masashi

AU - Nakano, Michiko

AU - Uozumi, Yasuhiro

AU - Kobayashi, Jun'ichi

N1 - Funding Information: The authors thank Ms. S. Oka and Ms. M. Kiuchi, Center for Instrumental Analysis, Hokkaido University, for measurements of FABMS. This work was partly supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan.

PY - 2006/6/26

Y1 - 2006/6/26

N2 - Amphezonol A (1), a novel polyhydroxyl linear carbon-chain metabolite, has been isolated from the cultured marine dinoflagellate Amphidinium sp., which was isolated from an Okinawan marine acoel flatworm Amphiscolops sp. The structure of 1 was elucidated by detailed analyses of 2D NMR spectra. Amphezonol A (1) possesses one tetrahydrofuran ring, two tetrahydropyran rings, and twenty-one hydroxyl groups on C60-linear aliphatic chain with one exo-methylene and one methyl branch. Amphezonol A (1) exhibited a modest inhibitory activity against DNA polymerase α.

AB - Amphezonol A (1), a novel polyhydroxyl linear carbon-chain metabolite, has been isolated from the cultured marine dinoflagellate Amphidinium sp., which was isolated from an Okinawan marine acoel flatworm Amphiscolops sp. The structure of 1 was elucidated by detailed analyses of 2D NMR spectra. Amphezonol A (1) possesses one tetrahydrofuran ring, two tetrahydropyran rings, and twenty-one hydroxyl groups on C60-linear aliphatic chain with one exo-methylene and one methyl branch. Amphezonol A (1) exhibited a modest inhibitory activity against DNA polymerase α.

KW - Amphezonol A

KW - Amphidinium sp.

KW - Dinoflagellate

KW - Polyhydroxyl metabolite

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U2 - 10.1016/j.tetlet.2006.04.094

DO - 10.1016/j.tetlet.2006.04.094

M3 - Article

AN - SCOPUS:33646761334

SN - 0040-4039

VL - 47

SP - 4369

EP - 4371

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 26

ER -

Amphezonol A, a novel polyhydroxyl metabolite from marine dinoflagellate Amphidinium sp.

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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