Research output: Chapter in Book/Report/Conference proceedingChapter


Amylin (AMY) is a member of the calcitonin gene-related peptide (CGRP) family and consists of a single intramolecular ring structure and an amidated C-terminus, which are common to the family members. AMY is cosecreted with insulin from pancreatic β cells and is considered to be involved in glucose homeostasis. AMY is normally in a soluble monomeric state, but forms amyloid fibrils and eventually leads to the aggregation of the islet amyloid in patients with type 2 diabetes. The human AMY20-29 region is responsible for fibril formation, and synthesized AMY based on the rat sequence with the variation in the region is used for the treatment of type 1 and type 2 diabetes. Iapp KO mice show increased insulin responses, high systolic blood pressure, and reduced nociceptive hypersensitivity.

Original languageEnglish
Title of host publicationHandbook of Hormones
Subtitle of host publicationComparative Endocrinology for Basic and Clinical Research
Number of pages3
ISBN (Electronic)9780128206492
Publication statusPublished - Jan 1 2021


  • Insulin
  • Islet amyloid
  • Pancreas and glucose homeostasis
  • Type 2 diabetes

ASJC Scopus subject areas

  • Medicine(all)


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