Amylin

Maho Ogoshi

doi:10.1016/B978-0-12-820649-2.00110-8

Amylin

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Amylin (AMY) is a member of the calcitonin gene-related peptide (CGRP) family and consists of a single intramolecular ring structure and an amidated C-terminus, which are common to the family members. AMY is cosecreted with insulin from pancreatic β cells and is considered to be involved in glucose homeostasis. AMY is normally in a soluble monomeric state, but forms amyloid fibrils and eventually leads to the aggregation of the islet amyloid in patients with type 2 diabetes. The human AMY20-29 region is responsible for fibril formation, and synthesized AMY based on the rat sequence with the variation in the region is used for the treatment of type 1 and type 2 diabetes. Iapp KO mice show increased insulin responses, high systolic blood pressure, and reduced nociceptive hypersensitivity.

Original language	English
Title of host publication	Handbook of Hormones
Subtitle of host publication	Comparative Endocrinology for Basic and Clinical Research
Publisher	Elsevier
Pages	425-427
Number of pages	3
ISBN (Electronic)	9780128206492
DOIs	https://doi.org/10.1016/B978-0-12-820649-2.00110-8
Publication status	Published - Jan 1 2021

Keywords

Insulin
Islet amyloid
Pancreas and glucose homeostasis
Type 2 diabetes

ASJC Scopus subject areas

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/B978-0-12-820649-2.00110-8

Cite this

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abstract = "Amylin (AMY) is a member of the calcitonin gene-related peptide (CGRP) family and consists of a single intramolecular ring structure and an amidated C-terminus, which are common to the family members. AMY is cosecreted with insulin from pancreatic β cells and is considered to be involved in glucose homeostasis. AMY is normally in a soluble monomeric state, but forms amyloid fibrils and eventually leads to the aggregation of the islet amyloid in patients with type 2 diabetes. The human AMY20-29 region is responsible for fibril formation, and synthesized AMY based on the rat sequence with the variation in the region is used for the treatment of type 1 and type 2 diabetes. Iapp KO mice show increased insulin responses, high systolic blood pressure, and reduced nociceptive hypersensitivity.",

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AB - Amylin (AMY) is a member of the calcitonin gene-related peptide (CGRP) family and consists of a single intramolecular ring structure and an amidated C-terminus, which are common to the family members. AMY is cosecreted with insulin from pancreatic β cells and is considered to be involved in glucose homeostasis. AMY is normally in a soluble monomeric state, but forms amyloid fibrils and eventually leads to the aggregation of the islet amyloid in patients with type 2 diabetes. The human AMY20-29 region is responsible for fibril formation, and synthesized AMY based on the rat sequence with the variation in the region is used for the treatment of type 1 and type 2 diabetes. Iapp KO mice show increased insulin responses, high systolic blood pressure, and reduced nociceptive hypersensitivity.

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KW - Islet amyloid

KW - Pancreas and glucose homeostasis

KW - Type 2 diabetes

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BT - Handbook of Hormones

PB - Elsevier

ER -

Amylin

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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