Abstract

AMY is a member of the calcitonin gene-related peptide (CGRP) family and consists of a single intramolecular ring structure and amidated C-terminus, which are common to the family members. AMY is co-secreted with insulin from pancreatic β cells and is considered to be involved in glucose homeostasis. AMY is normally in a soluble monomeric state, but forms amyloid fibrils and eventually leads to the aggregation of islet amyloid in patients with type 2 diabetes. The human AMY 20–29 region is responsible for fibril formation, and synthesized AMY based on the rat sequence with the variation in the region is used for treatment of type 1 and type 2 diabetes. AMY KO mice show increased insulin responses, high systolic blood pressure, and reduced nociceptive hypersensitivity.

Original languageEnglish
Title of host publicationHandbook of Hormones
Subtitle of host publicationComparative Endocrinology for Basic and Clinical Research
PublisherElsevier
Pages245,e27F-1-246,e27F-3
ISBN (Electronic)9780128010280
ISBN (Print)9780128010679
DOIs
Publication statusPublished - Jan 1 2015

Keywords

  • glucose homeostasis
  • insulin
  • islet amyloid
  • pancreas
  • type 2 diabetes

ASJC Scopus subject areas

  • General Medicine

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