An alteration of ganglioside composition in cisplatin-resistant lung cancer cell line

Katsuyuki Kiura; Shinobu Watarai; Hiroshi Ueoka; Masahiro Tabata; Ken Ichi Gemba; Keisuke Aoe; Hiromichi Yamane; Tatsuji Yasuda; Mine Harada

An alteration of ganglioside composition in cisplatin-resistant lung cancer cell line

Katsuyuki Kiura, Shinobu Watarai, Hiroshi Ueoka, Masahiro Tabata, Ken Ichi Gemba, Keisuke Aoe, Hiromichi Yamane, Tatsuji Yasuda, Mine Harada

University Hospital

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Previously we established cell lines resistant to Adriamycin and cisplatin to elucidate the mechanisins involved in acquired drug-resistance. In this study, we investigated ganglioside composition in drug-resistant cell lines. The Adriamycin-resistant cell line, SBC-3/ADM100, exhibited a ganglioside composition ratio similar to that of the parent SBC-3 cells. Densitometric analysis by resorcinol showed a 1.61-fold increase of ganglioside GM2 in SBC-3/ADM100 cells, when compared to the parent SBC-3 cells. The cisplatin-resistant cell line, SBC-3/CDDP, showed a simplified ganglioside pattern, expressing only gangliosides GM3 and GM2. SBC-3/CDDP cells showed a marked increase in ganglioside GM3. These findings suggest that the alteration of ganglioside composition may be actively involved in the acquisition of drug-resistance.

Original language	English
Pages (from-to)	2957-2960
Number of pages	4
Journal	Anticancer research
Volume	18
Issue number	4 C
Publication status	Published - Jul 1 1998

Keywords

Cisplatin
GM3
Ganglioside
Small-cell lung cancer

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "An alteration of ganglioside composition in cisplatin-resistant lung cancer cell line",

abstract = "Previously we established cell lines resistant to Adriamycin and cisplatin to elucidate the mechanisins involved in acquired drug-resistance. In this study, we investigated ganglioside composition in drug-resistant cell lines. The Adriamycin-resistant cell line, SBC-3/ADM100, exhibited a ganglioside composition ratio similar to that of the parent SBC-3 cells. Densitometric analysis by resorcinol showed a 1.61-fold increase of ganglioside GM2 in SBC-3/ADM100 cells, when compared to the parent SBC-3 cells. The cisplatin-resistant cell line, SBC-3/CDDP, showed a simplified ganglioside pattern, expressing only gangliosides GM3 and GM2. SBC-3/CDDP cells showed a marked increase in ganglioside GM3. These findings suggest that the alteration of ganglioside composition may be actively involved in the acquisition of drug-resistance.",

keywords = "Cisplatin, GM3, Ganglioside, Small-cell lung cancer",

author = "Katsuyuki Kiura and Shinobu Watarai and Hiroshi Ueoka and Masahiro Tabata and Gemba, {Ken Ichi} and Keisuke Aoe and Hiromichi Yamane and Tatsuji Yasuda and Mine Harada",

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T1 - An alteration of ganglioside composition in cisplatin-resistant lung cancer cell line

AU - Kiura, Katsuyuki

AU - Watarai, Shinobu

AU - Ueoka, Hiroshi

AU - Tabata, Masahiro

AU - Gemba, Ken Ichi

AU - Aoe, Keisuke

AU - Yamane, Hiromichi

AU - Yasuda, Tatsuji

AU - Harada, Mine

PY - 1998/7/1

Y1 - 1998/7/1

N2 - Previously we established cell lines resistant to Adriamycin and cisplatin to elucidate the mechanisins involved in acquired drug-resistance. In this study, we investigated ganglioside composition in drug-resistant cell lines. The Adriamycin-resistant cell line, SBC-3/ADM100, exhibited a ganglioside composition ratio similar to that of the parent SBC-3 cells. Densitometric analysis by resorcinol showed a 1.61-fold increase of ganglioside GM2 in SBC-3/ADM100 cells, when compared to the parent SBC-3 cells. The cisplatin-resistant cell line, SBC-3/CDDP, showed a simplified ganglioside pattern, expressing only gangliosides GM3 and GM2. SBC-3/CDDP cells showed a marked increase in ganglioside GM3. These findings suggest that the alteration of ganglioside composition may be actively involved in the acquisition of drug-resistance.

AB - Previously we established cell lines resistant to Adriamycin and cisplatin to elucidate the mechanisins involved in acquired drug-resistance. In this study, we investigated ganglioside composition in drug-resistant cell lines. The Adriamycin-resistant cell line, SBC-3/ADM100, exhibited a ganglioside composition ratio similar to that of the parent SBC-3 cells. Densitometric analysis by resorcinol showed a 1.61-fold increase of ganglioside GM2 in SBC-3/ADM100 cells, when compared to the parent SBC-3 cells. The cisplatin-resistant cell line, SBC-3/CDDP, showed a simplified ganglioside pattern, expressing only gangliosides GM3 and GM2. SBC-3/CDDP cells showed a marked increase in ganglioside GM3. These findings suggest that the alteration of ganglioside composition may be actively involved in the acquisition of drug-resistance.

KW - Cisplatin

KW - GM3

KW - Ganglioside

KW - Small-cell lung cancer

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IS - 4 C

ER -

An alteration of ganglioside composition in cisplatin-resistant lung cancer cell line

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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