An association of IgG anti-laminin-1 autoantibodies with endometriosis in infertile patients

Junko Inagaki, Mayumi Sugiura-Ogasawara, Motoyoshi Nomizu, Mikiya Nakatsuka, Katsuo Ikuta, Nobuharu Suzuki, Keiko Kaihara, Kazuko Kobayashi, Tatsuji Yasuda, Yehuda Shoenfeld, Koji Aoki, Eiji Matsuura

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)


Background: Laminin-1, a multifunctional glycoprotein of the basement membrane, is thought to be important in embryogenesis, embryonic implantation, and placentation. We recently showed that serum IgG anti-laminin-1 autoantibodies (auto-Abs) are associated with recurrent first-trimester miscarriages. The present study assessed the clinical significance of anti-laminin-1 Abs with infertility, accompanied with or without endometriosis. Methods: Sixty-eight infertile patients who underwent laparoscopy or laparotomy and 39 healthy non-pregnant women were tested for IgG anti-laminin-1 Abs. The association between the Abs and endometriosis was analysed. The presence of laminin-1 mRNA was detected in endometriotic lesions. Results: Twenty infertile patients were positive for anti-laminin-1 Abs. The Ab levels in those patients were significantly higher than those in healthy non-pregnant women (P = 0.0005). The presence of the Abs was significantly associated with endometriosis in those patients (P = 0.0096). The Abs recognized a particular domain, i.e., the laminin-α1 chain G domain. mRNA encoding laminin-α1, -β1, and -γ1 chains was expressed in 90% of endometriotic lesions. Conclusions: IgG anti-laminin-1 Abs were significantly associated with endometriosis in infertile patients. The Abs might be clinically important in the development of autoimmune-mediated reproductive failures and the assessment of the Abs may provide a novel non-invasive diagnosis of endometriosis.

Original languageEnglish
Pages (from-to)544-549
Number of pages6
JournalHuman Reproduction
Issue number3
Publication statusPublished - Mar 1 2003


  • Anti-laminin-1 autoantibody
  • Endometriosis
  • Infertility
  • Miscarriage

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology


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