An evaluation of the safety and feasibility of adenosine-assisted clipping surgery for unruptured cerebral aneurysms: Study protocol

Tomohito Hishikawa, Satoshi Murai, Masafumi Hiramatsu, Jun Haruma, Kazuhiko Nishi, Yuki Ebisudani, Yu Sato, Takao Yasuhara, Kenji Sugiu, Kazuyoshi Shimizu, Motomu Kobayashi, Koji Nakagawa, Aya Kimura-Ono, Katsuyuki Hotta, Hiroshi Morimatsu, Isao Date

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The effectiveness of adenosine-induced flow arrest in surgical clipping for the cerebral aneurysms with difficulties in temporary clip placement to the proximal main trunk has been reported. This is the first clinical trial to evaluate the safety and feasibility of adenosine-assisted clipping surgery for unruptured cerebral aneurysms (UCAs) in Japan. The inclusion criteria are as fol-lows: patients over 20 years old, patients who agree to be enrolled in this study after providing informed consent, patients who undergo clipping surgery for UCA in our institute, and patients in whom the surgeons (T.H. or I.D.) judge that decompression of the aneurysm is effective. The primary endpoint is a modified Rankin Scale (mRS) score 30 days after surgery. We plan to enroll 10 patients in this study. The original protocol of adenosine administration was established in this trial. Herein, we present the study protocol.

Original languageEnglish
Pages (from-to)393-396
Number of pages4
Journalneurologia medico-chirurgica
Volume61
Issue number7
DOIs
Publication statusPublished - 2021

Keywords

  • Adenosine
  • Clipping
  • Unruptured cerebral aneurysm

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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