TY - JOUR
T1 - Analysis of 2897 hospitalization events for patients with chronic kidney disease
T2 - results from CKD-JAC study
AU - for the CKD-JAC Investigators
AU - Iimuro, Satoshi
AU - Kaneko, Tetsuji
AU - Ohashi, Yasuo
AU - Watanabe, Tsuyoshi
AU - Nitta, Kosaku
AU - Akizawa, Tadao
AU - Matsuo, Seiichi
AU - Imai, Enyu
AU - Makino, Hirofumi
AU - Hishida, Akira
N1 - Funding Information:
Conflict of interest SI and TK received a research support grant from Kyowa Hakko Kirin; KN received a research support grant from Ky-owa Hakko Kirin; TA received consultancy and lecture fees from Ky-owa Hakko Kirin; SM received lecture fees from Kyowa Hakko Kirin; HM received speaker honoraria from Kyowa Hakko Kirin. The other authors have no conflicts of interest to declare. This study was supported by research funds with no restriction on publication from Ky-owa Hakko Kirin Co., Ltd.
Funding Information:
This study was conducted by the principal investigators at the following medical centers: Japan Community Health Care Organization Sendai Hospital (Miyagi), JA Toride Medical Center (Ibaraki), Jichi Medical University (Tochigi), Tokyo Women’s Medical University Hospital (Tokyo), St. Luke’s International Hospital (Tokyo), Showa University Hospital (Tokyo), Showa University Yokohama Northern Hospital (Kanagawa), Showa University Fujigaoka Hospital (Kanagawa), Gifu Prefectural General Medical Center (Gifu), Kasugai Municipal Hospital (Aichi), Tosei General Hospital (Aichi), Osaka University Hospital (Osaka), Osaka General Medical Center (Osaka), Osaka City General Hospital (Osaka), Kurashiki Central Hospital (Okayama), Fukuoka Red Cross Hospital (Fukuoka), and Iizuka Hospital (Fukuoka).
Publisher Copyright:
© 2019, The Author(s).
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Background: Chronic kidney disease is a known risk factor for end-stage renal and cardiovascular diseases. However, data are limited on the causes of hospitalization in patients with chronic kidney disease of maintenance period. This study aimed to aggregate hospitalization data of CKD patients and to determine the high-risk population. In addition, we compared CKD population to general population. Methods: We conducted a post hoc analysis of the chronic kidney disease-Japan cohort study, a multicenter prospective cohort study of 2966 patients with chronic kidney disease with a median 3.9 years of follow-up. We examined the hospitalization reasons and analyzed the risk factors. Results: We found 2897 all-cause hospitalization events (252.3 events/1000 person-years), a hospitalization incidence 17.1-fold higher than that in an age- and sex-matched cohort from the general Japanese population. Kidney, eye and adnexa, and heart-related hospital admissions were the most common. All-cause hospitalization increased with chronic kidney disease stage and with the presence of diabetes. Patients with diabetes at enrollment had 345.7 hospitalization events/1000 person-years, which is considerably higher than 196.8 events/1000 person-years for those without diabetes. Survival analysis, using hospitalization as an event, showed earlier all-cause hospitalization with the progression of chronic kidney disease stage and diabetes. Cardiovascular disease hospitalizations were more strongly influenced by diabetes than chronic kidney disease stage. Conclusions: Patients with chronic kidney disease and diabetes are highly vulnerable to hospitalization for a variety of diseases. These descriptive data can be valuable in predicting the prognosis of patients with chronic kidney disease.
AB - Background: Chronic kidney disease is a known risk factor for end-stage renal and cardiovascular diseases. However, data are limited on the causes of hospitalization in patients with chronic kidney disease of maintenance period. This study aimed to aggregate hospitalization data of CKD patients and to determine the high-risk population. In addition, we compared CKD population to general population. Methods: We conducted a post hoc analysis of the chronic kidney disease-Japan cohort study, a multicenter prospective cohort study of 2966 patients with chronic kidney disease with a median 3.9 years of follow-up. We examined the hospitalization reasons and analyzed the risk factors. Results: We found 2897 all-cause hospitalization events (252.3 events/1000 person-years), a hospitalization incidence 17.1-fold higher than that in an age- and sex-matched cohort from the general Japanese population. Kidney, eye and adnexa, and heart-related hospital admissions were the most common. All-cause hospitalization increased with chronic kidney disease stage and with the presence of diabetes. Patients with diabetes at enrollment had 345.7 hospitalization events/1000 person-years, which is considerably higher than 196.8 events/1000 person-years for those without diabetes. Survival analysis, using hospitalization as an event, showed earlier all-cause hospitalization with the progression of chronic kidney disease stage and diabetes. Cardiovascular disease hospitalizations were more strongly influenced by diabetes than chronic kidney disease stage. Conclusions: Patients with chronic kidney disease and diabetes are highly vulnerable to hospitalization for a variety of diseases. These descriptive data can be valuable in predicting the prognosis of patients with chronic kidney disease.
KW - Cardiovascular disease
KW - Diabetes mellitus
KW - Diabetic kidney disease
KW - Japanese patient survey 2008
KW - Pre-renal replacement therapy
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U2 - 10.1007/s10157-019-01730-9
DO - 10.1007/s10157-019-01730-9
M3 - Article
C2 - 30968244
AN - SCOPUS:85066930821
SN - 1342-1751
VL - 23
SP - 956
EP - 968
JO - Clinical and Experimental Nephrology
JF - Clinical and Experimental Nephrology
IS - 7
ER -
