Analysis of lipoprotein metabolism in alcoholics

Yuki Mizukami, Mitsuyo Okazaki, Shinichi Usui, Seijin Hosaki, Katsuya Maruyama, Y. Hosokawa

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


High density lipoprotein (HDL) is increased by exercise and drinking and is well known as a negative risk factor of coronary heart disease. We analyzed serum lipids of alcoholics from the view points of biochemical examination, remnant like particle (RLP) and particle size of lipoprotein for the purpose of estimated effect of serum lipids, especially HDL quality in alcoholics. Serum levels of total cholesterol, free glycerol, RLP-C and RLP-TG were significantly decreased after hospitalization. The condition of RLP-C/RLP-TG on admission revealed cholesterol-rich composition. In case of HDL-C, the longer period from last drinking to hospitalization affected its decrease. From analytical study of particle size of lipoprotein, quantities of HDL-C in very large size and large size were significantly decreased after hospitalization which means that HDL composition at hospitalization is cholesterol-rich. So, it is speculated that increased serum level of HDL in alcoholics may be caused by expanded cholesterol ester and its quality may be different from that of healthy people. In this meaning, the study of arteriosclerosis in alcoholics will be necessary in relation to high level of serum HDL-C.

Original languageEnglish
Pages (from-to)110-119
Number of pages10
JournalNihon Arukōru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence
Issue number2
Publication statusPublished - Apr 1 2008
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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