Analysis of risk factors for colonic diverticular bleeding: a matched case-control study

Yuusaku Sugihara, Shin Ei Kudo, Hideyuki Miyachi, Masashi Misawa, Shogo Okoshi, Hiroyuki Okada, Kazuhide Yamamoto

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Background/Aims: Diverticular bleeding can occasionally cause massive bleeding that requires urgent colonoscopy (CS) and treatment. The aim of this study was to identify significant risk factors for colonic diverticular hemorrhage. Methods: Between January 2009 and December 2012, 26,602 patients underwent CS at our institution. One hundred twenty-three patients underwent an urgent CS due to acute lower gastrointestinal hemorrhage. Seventy-two patients were diagnosed with colonic diverticular hemorrhage. One hundred forty-nine age- and sex-matched controls were selected from the patients with nonbleeding diverticula who underwent CS during the same period. The relationship of risk factors to diverticular bleeding was compared between the cases and controls. Results: Uni- and multivariate conditional logistic regression analyses demonstrated that the use of nonsteroidal anti-inflammatory drugs (odds ratio [OR], 14.70; 95% confidence interval [CI], 3.89 to 55.80; p<0.0001), as well as the presence of cerebrovascular disease (OR, 8.66; 95% CI, 2.33 to 32.10; p=0.00126), and hyperuricemia (OR, 15.5; 95% CI, 1.74 to 138.00; p=0.014) remained statistically significant predictors of diverticular bleeding. Conclusions: Nonsteroidal anti-inflammatory drugs, cerebrovascular disease and hyperuricemia were significant risks for colonic diverticular hemorrhage. The knowledge obtained from this study may provide some insight into the diagnostic process for patients with lower gastrointestinal bleeding.

Original languageEnglish
Pages (from-to)244-249
Number of pages6
JournalGut and liver
Issue number2
Publication statusPublished - Mar 2016


  • Anti-inflammatory agents
  • Cerebrovascular disease
  • Colonoscopy
  • Diverticular bleeding
  • Hyperuricemia
  • Non-steroidal

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


Dive into the research topics of 'Analysis of risk factors for colonic diverticular bleeding: a matched case-control study'. Together they form a unique fingerprint.

Cite this