TY - JOUR
T1 - Analysis of the relationship between periodontal disease and atherosclerosis within a local clinical system
T2 - a cross-sectional observational pilot study
AU - Kudo, Chieko
AU - Shin, Wee Soo
AU - Minabe, Masato
AU - Harai, Kazuo
AU - Kato, Kai
AU - Seino, Hiroaki
AU - Goke, Eiji
AU - Sasaki, Nobuhiro
AU - Fujino, Takemasa
AU - Kuribayashi, Nobuichi
AU - Pearce, Youko Onuki
AU - Taira, Masato
AU - Maeda, Hiroshi
AU - Takashiba, Shogo
N1 - Funding Information:
This study was supported by Grant-in-planning for Advanced Research (H22) from Japanese Society of Periodontology.
Publisher Copyright:
© 2014, The Society of The Nippon Dental University.
PY - 2015/9/23
Y1 - 2015/9/23
N2 - It has been revealed that atherosclerosis and periodontal disease may have a common mechanism of “chronic inflammation”. Several reports have indicated that periodontal infection is related to atherosclerosis, but none have yet reported such an investigation through the cooperation of local clinics. This study was performed in local Japanese clinics to examine the relationship between periodontal disease and atherosclerosis under collaborative medical and dental care. A pilot multicenter cross-sectional study was conducted on 37 medical patients with lifestyle-related diseases under consultation in participating medical clinics, and 79 periodontal patients not undergoing medical treatment but who were seen by participating dental clinics. Systemic examination and periodontal examination were performed at baseline, and the relationships between periodontal and atherosclerosis-related clinical markers were analyzed. There was a positive correlation between LDL-C level and plasma IgG antibody titer to Porphyromonas gingivalis. According to the analysis under adjusted age, at a cut-off value of 5.04 for plasma IgG titer to Porphyromonas gingivalis, the IgG titer was significantly correlated with the level of low-density lipoprotein cholesterol (LDL-C). This study suggested that infection with periodontal bacteria (Porphyromonas gingivalis) is associated with the progression of atherosclerosis. Plasma IgG titer to Porphyromonas gingivalis may be useful as the clinical risk marker for atherosclerosis related to periodontal disease. Moreover, the application of the blood examination as a medical check may lead to the development of collaborative medical and dental care within the local medical clinical system for the purpose of preventing the lifestyle-related disease.
AB - It has been revealed that atherosclerosis and periodontal disease may have a common mechanism of “chronic inflammation”. Several reports have indicated that periodontal infection is related to atherosclerosis, but none have yet reported such an investigation through the cooperation of local clinics. This study was performed in local Japanese clinics to examine the relationship between periodontal disease and atherosclerosis under collaborative medical and dental care. A pilot multicenter cross-sectional study was conducted on 37 medical patients with lifestyle-related diseases under consultation in participating medical clinics, and 79 periodontal patients not undergoing medical treatment but who were seen by participating dental clinics. Systemic examination and periodontal examination were performed at baseline, and the relationships between periodontal and atherosclerosis-related clinical markers were analyzed. There was a positive correlation between LDL-C level and plasma IgG antibody titer to Porphyromonas gingivalis. According to the analysis under adjusted age, at a cut-off value of 5.04 for plasma IgG titer to Porphyromonas gingivalis, the IgG titer was significantly correlated with the level of low-density lipoprotein cholesterol (LDL-C). This study suggested that infection with periodontal bacteria (Porphyromonas gingivalis) is associated with the progression of atherosclerosis. Plasma IgG titer to Porphyromonas gingivalis may be useful as the clinical risk marker for atherosclerosis related to periodontal disease. Moreover, the application of the blood examination as a medical check may lead to the development of collaborative medical and dental care within the local medical clinical system for the purpose of preventing the lifestyle-related disease.
KW - Atherosclerosis
KW - Collaborative medical and dental care
KW - Low-density lipoprotein cholesterol
KW - Periodontal disease
KW - Plasma IgG titer to Porphyromonas gingivalis
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U2 - 10.1007/s10266-014-0172-3
DO - 10.1007/s10266-014-0172-3
M3 - Article
C2 - 25119713
AN - SCOPUS:84941993807
SN - 1618-1247
VL - 103
SP - 314
EP - 321
JO - Odontology
JF - Odontology
IS - 3
ER -