Anaphylaxis after rabies vaccination for dogs in japan

Megumi Yoshida, Keijiro Mizukami, Masaharu Hisasue, Ichiro Imanishi, Keigo Kurata, Masaki Ochiai, Masato Itoh, Tadahiro Nasukawa, Jumpei Uchiyama, Hajime Tsujimoto, Masahiro Sakaguchi

Research output: Contribution to journalComment/debatepeer-review

1 Citation (Scopus)


Severe adverse reactions after rabies vaccination in dogs were examined from 317 cases reported to the Ministry of Agriculture, Forestry and Fisheries (MAFF) in Japan during 15-year period from April 2004 to March 2019. We found that 109 of the 317 dogs showed anaphylaxis (0.15/100,000 vaccinated dogs), and 71 of the 109 cases of anaphylaxis resulted in death (0.10/100,000 vaccinated dogs). We measured bovine serum albumin (BSA) in four commercially available rabies vaccines and found the levels ranged from 0.1 to 16.6 µg/dose. Our survey showed that the rate of anaphylaxis to rabies vaccines in dogs is rare, although some cases of anaphylaxis resulted in death. Veterinarians should be well prepared to deal with vaccine-associated anaphylaxis.

Original languageEnglish
Pages (from-to)1202-1205
Number of pages4
JournalJournal of Veterinary Medical Science
Issue number8
Publication statusPublished - 2021
Externally publishedYes


  • Adverse reaction
  • Anaphylaxis
  • Dog
  • Rabies vaccine

ASJC Scopus subject areas

  • veterinary(all)


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