Anaphylaxis after rabies vaccination for dogs in japan

Megumi Yoshida; Keijiro Mizukami; Masaharu Hisasue; Ichiro Imanishi; Keigo Kurata; Masaki Ochiai; Masato Itoh; Tadahiro Nasukawa; Jumpei Uchiyama; Hajime Tsujimoto; Masahiro Sakaguchi

doi:10.1292/jvms.21-0090

Anaphylaxis after rabies vaccination for dogs in japan

Megumi Yoshida, Keijiro Mizukami, Masaharu Hisasue, Ichiro Imanishi, Keigo Kurata, Masaki Ochiai, Masato Itoh, Tadahiro Nasukawa, Jumpei Uchiyama, Hajime Tsujimoto, Masahiro Sakaguchi

Research output: Contribution to journal › Comment/debate › peer-review

1 Citation (Scopus)

Abstract

Severe adverse reactions after rabies vaccination in dogs were examined from 317 cases reported to the Ministry of Agriculture, Forestry and Fisheries (MAFF) in Japan during 15-year period from April 2004 to March 2019. We found that 109 of the 317 dogs showed anaphylaxis (0.15/100,000 vaccinated dogs), and 71 of the 109 cases of anaphylaxis resulted in death (0.10/100,000 vaccinated dogs). We measured bovine serum albumin (BSA) in four commercially available rabies vaccines and found the levels ranged from 0.1 to 16.6 µg/dose. Our survey showed that the rate of anaphylaxis to rabies vaccines in dogs is rare, although some cases of anaphylaxis resulted in death. Veterinarians should be well prepared to deal with vaccine-associated anaphylaxis.

Original language	English
Pages (from-to)	1202-1205
Number of pages	4
Journal	Journal of Veterinary Medical Science
Volume	83
Issue number	8
DOIs	https://doi.org/10.1292/jvms.21-0090
Publication status	Published - 2021
Externally published	Yes

Keywords

Adverse reaction
Anaphylaxis
Dog
Rabies vaccine

ASJC Scopus subject areas

veterinary(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1292/jvms.21-0090

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title = "Anaphylaxis after rabies vaccination for dogs in japan",

abstract = "Severe adverse reactions after rabies vaccination in dogs were examined from 317 cases reported to the Ministry of Agriculture, Forestry and Fisheries (MAFF) in Japan during 15-year period from April 2004 to March 2019. We found that 109 of the 317 dogs showed anaphylaxis (0.15/100,000 vaccinated dogs), and 71 of the 109 cases of anaphylaxis resulted in death (0.10/100,000 vaccinated dogs). We measured bovine serum albumin (BSA) in four commercially available rabies vaccines and found the levels ranged from 0.1 to 16.6 µg/dose. Our survey showed that the rate of anaphylaxis to rabies vaccines in dogs is rare, although some cases of anaphylaxis resulted in death. Veterinarians should be well prepared to deal with vaccine-associated anaphylaxis.",

keywords = "Adverse reaction, Anaphylaxis, Dog, Rabies vaccine",

author = "Megumi Yoshida and Keijiro Mizukami and Masaharu Hisasue and Ichiro Imanishi and Keigo Kurata and Masaki Ochiai and Masato Itoh and Tadahiro Nasukawa and Jumpei Uchiyama and Hajime Tsujimoto and Masahiro Sakaguchi",

note = "Funding Information: ACKNOWLEDGMENTS. This study was supported by Ministry of Education, Culture, Sports, Science and Technology-Supported Program for the Private University Research Branding Project, 2016–2020. Publisher Copyright: {\textcopyright}2021 The Japanese Society of Veterinary Science.",

year = "2021",

doi = "10.1292/jvms.21-0090",

language = "English",

volume = "83",

pages = "1202--1205",

journal = "Journal of Veterinary Medical Science",

issn = "0916-7250",

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}

TY - JOUR

T1 - Anaphylaxis after rabies vaccination for dogs in japan

AU - Yoshida, Megumi

AU - Mizukami, Keijiro

AU - Hisasue, Masaharu

AU - Imanishi, Ichiro

AU - Kurata, Keigo

AU - Ochiai, Masaki

AU - Itoh, Masato

AU - Nasukawa, Tadahiro

AU - Uchiyama, Jumpei

AU - Tsujimoto, Hajime

AU - Sakaguchi, Masahiro

N1 - Funding Information: ACKNOWLEDGMENTS. This study was supported by Ministry of Education, Culture, Sports, Science and Technology-Supported Program for the Private University Research Branding Project, 2016–2020. Publisher Copyright: ©2021 The Japanese Society of Veterinary Science.

PY - 2021

Y1 - 2021

N2 - Severe adverse reactions after rabies vaccination in dogs were examined from 317 cases reported to the Ministry of Agriculture, Forestry and Fisheries (MAFF) in Japan during 15-year period from April 2004 to March 2019. We found that 109 of the 317 dogs showed anaphylaxis (0.15/100,000 vaccinated dogs), and 71 of the 109 cases of anaphylaxis resulted in death (0.10/100,000 vaccinated dogs). We measured bovine serum albumin (BSA) in four commercially available rabies vaccines and found the levels ranged from 0.1 to 16.6 µg/dose. Our survey showed that the rate of anaphylaxis to rabies vaccines in dogs is rare, although some cases of anaphylaxis resulted in death. Veterinarians should be well prepared to deal with vaccine-associated anaphylaxis.

AB - Severe adverse reactions after rabies vaccination in dogs were examined from 317 cases reported to the Ministry of Agriculture, Forestry and Fisheries (MAFF) in Japan during 15-year period from April 2004 to March 2019. We found that 109 of the 317 dogs showed anaphylaxis (0.15/100,000 vaccinated dogs), and 71 of the 109 cases of anaphylaxis resulted in death (0.10/100,000 vaccinated dogs). We measured bovine serum albumin (BSA) in four commercially available rabies vaccines and found the levels ranged from 0.1 to 16.6 µg/dose. Our survey showed that the rate of anaphylaxis to rabies vaccines in dogs is rare, although some cases of anaphylaxis resulted in death. Veterinarians should be well prepared to deal with vaccine-associated anaphylaxis.

KW - Adverse reaction

KW - Anaphylaxis

KW - Dog

KW - Rabies vaccine

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U2 - 10.1292/jvms.21-0090

DO - 10.1292/jvms.21-0090

M3 - Comment/debate

C2 - 34108336

AN - SCOPUS:85111738601

SN - 0916-7250

VL - 83

SP - 1202

EP - 1205

JO - Journal of Veterinary Medical Science

JF - Journal of Veterinary Medical Science

IS - 8

ER -

Anaphylaxis after rabies vaccination for dogs in japan

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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