Anaphylaxis after vaccination for cats in Japan

Megumi Yoshida, Keijiro Mizukami, Masaharu Hisasue, Ichiro Imanishi, Keigo Kurata, Masaki Ochiai, Masato Itoh, Tadahiro Nasukawa, Jumpei Uchiyama, Hajime Tsujimoto, Masahiro Sakaguchi

Research output: Contribution to journalComment/debatepeer-review

1 Citation (Scopus)


Severe adverse reactions in cats after vaccination were examined from 316 cases reported to the Ministry of Agriculture, Forestry and Fisheries (MAFF) in Japan during 15-year period from April 2004 to March 2019. We found that 130 (41%) showed anaphylaxis, and 99 (76%) of the 130 cases of anaphylaxis resulted in death. Veterinarians should be well prepared to deal with vaccine-associated anaphylaxis in cats. Bovine serum albumin (BSA) as indicator of purification was detected at high levels in commercially available feline vaccines. BSA might derive from fetal calf serum in culture media. This study provides useful information about anaphylaxis including critical details of the potential clinical signs associated with adverse events to feline vaccination.

Original languageEnglish
Pages (from-to)149-152
Number of pages4
JournalJournal of Veterinary Medical Science
Issue number1
Publication statusPublished - Jan 2022
Externally publishedYes


  • Adverse reaction
  • Anaphylaxis
  • Bovine serum albumin
  • Feline vaccine

ASJC Scopus subject areas

  • veterinary(all)


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