TY - JOUR
T1 - Andirolides H-P from the flower of andiroba (Carapa guianensis, Meliaceae)
AU - Tanaka, Yuji
AU - Sakamoto, Asami
AU - Inoue, Takanobu
AU - Yamada, Takeshi
AU - Kikuchi, Takashi
AU - Kajimoto, Tetsuya
AU - Muraoka, Osamu
AU - Sato, Akira
AU - Wataya, Yusuke
AU - Kim, Hye Sook
AU - Tanaka, Reiko
N1 - Funding Information:
We thank Mr. Akira Yoshino for the collection and identification of the plant material. We also thank Dr. Katsuhiko Minoura and Mrs. Mihoyo Fujitake (this University) for NMR and MS measurements. This work was supported by a Grant-in-Aid for High Technology from the Ministry of Education, Culture, Sports, Science and Technology , Japan, partially supported by the Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation , and Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology , Japan.
PY - 2012/5/6
Y1 - 2012/5/6
N2 - Three new gedunins, an andirobin, three mexicanolides, and two phragmalin-type limonoids named andirolides H (1), I (2), J (3), K (4), L (5), M (6), N (7), O (8), and P (9) were isolated from an oil of the flower of Carapa guianensis Aublet (Meliaceae). Their structures including the absolute configurations were determined by means of the NMR and CD spectra as well as FABMS. Andirolide H (1) showed antimalarial activity against Plasmodium falciparum in vitro.
AB - Three new gedunins, an andirobin, three mexicanolides, and two phragmalin-type limonoids named andirolides H (1), I (2), J (3), K (4), L (5), M (6), N (7), O (8), and P (9) were isolated from an oil of the flower of Carapa guianensis Aublet (Meliaceae). Their structures including the absolute configurations were determined by means of the NMR and CD spectra as well as FABMS. Andirolide H (1) showed antimalarial activity against Plasmodium falciparum in vitro.
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U2 - 10.1016/j.tet.2011.12.076
DO - 10.1016/j.tet.2011.12.076
M3 - Article
AN - SCOPUS:84862785793
SN - 0040-4020
VL - 68
SP - 3669
EP - 3677
JO - Tetrahedron
JF - Tetrahedron
IS - 18
ER -