Angiogenic squamous dysplasia-like phenomenon in oral epithelial precursor lesions

C. H. Siar, V. P.A. Oo, H. Nagatsuka, K. Nakano, K. H. Ng, T. Kawakami

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Statement of the problem: Dysplasia, the morphological yardstick of epithelial precursor lesions, is the collective term for a variety of architectural and cytological changes within the altered oral epithelium. Angiogenic squamous dysplasia (ASD), a distinct morphological characteristic in pre-invasive bronchial lesions, describes the presence of capillary tufts that are closely juxtaposed to and projecting into the dysplastic bronchial epithelium. Objective: To determine whether ASD-like phenomenon occurs in oral epithelial precursor lesions, and to speculate on its relevance. Methods: Twenty cases each of mild, moderate and severe oral dysplasia (inclusive of carcinoma-in-situ), and 10 normal oral mucosa (normal controls) were serial sectioned for H and E staining, and for microvessel density (MVD) scoring with CD31, CD34 and CD105. Microcapillary pattern images were digitally captured for 3-D reconstruction. Results: Oral ASD foci consisting of CD31- and CD34-positive capillary loops abutting onto the overlying dysplastic oral epithelium (and causing it to assume an irregular or papillary surface configuration) were identified in moderate (3/20; 15%) and severe dysplasia (13/20; 65%), but not in normal oral mucosa and mild dysplasia. MVD score demonstrated increasing vascularity as epithelium progressed from normal to severe dysplasia (p<0.05). CD105 demonstrated increase neovascularization in all dysplasia grades (p<0.05). Conclusions: These preliminary findings taken together suggest that: 1. ASD-like phenomenon may be an important intermediary biomarker in oral precursor lesions; and 2. architectural alterations of the entire disturbed mucosa may be a more useful pre-malignancy index.

Original languageEnglish
Pages (from-to)315-319
Number of pages5
JournalEuropean journal of medical research
Issue number7
Publication statusPublished - Jul 22 2009


  • Angiogenic squamous dysplasia
  • CD105
  • CD31, CD34
  • Immunohistochemistry
  • Oral precursor lesions

ASJC Scopus subject areas

  • General Medicine


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