Angioimmunoblastic T-cell Lymphoma Presenting as a Methotrexate-associated Lymphoproliferative Disorder with Extreme Peripheral Blood Plasmacytosis

Hiroyuki Murakami; Masanori Makita; Tatsunori Ishikawa; Takanori Yoshioka; Keina Nagakita; Yoko Shinno; Tadashi Yoshino; Yoshinobu Maeda; Kazutaka Sunami

doi:10.2169/internalmedicine.8422-21

Angioimmunoblastic T-cell Lymphoma Presenting as a Methotrexate-associated Lymphoproliferative Disorder with Extreme Peripheral Blood Plasmacytosis

Hiroyuki Murakami, Masanori Makita, Tatsunori Ishikawa, Takanori Yoshioka, Keina Nagakita, Yoko Shinno, Tadashi Yoshino, Yoshinobu Maeda, Kazutaka Sunami

Research output: Contribution to journal › Article › peer-review

Abstract

A 74-year-old man was admitted to our hospital because of systemic lymphadenopathy, weight loss, and a fever at night that had persisted for approximately 1 month. Blood tests revealed extreme peripheral blood plasmacytosis and hypergammaglobulinemia. A lymph node biopsy showed angioimmunoblastic T-cell lymphoma (AITL). Based on the history of methotrexate (MTX) administration, the established diagnosis was MTX-associated lymphoproliferative disorder (MTX-LPD). After MTX was discontinued, the lymphadenopathy spontaneously regressed and the plasmacytosis disappeared. He had no disease progression for three years. We found that AITL as an MTX-LPD can cause plasmacytosis, and the prognosis of this disease may not be poor.

Original language	English
Pages (from-to)	2655-2660
Number of pages	6
Journal	Internal Medicine
Volume	61
Issue number	17
DOIs	https://doi.org/10.2169/internalmedicine.8422-21
Publication status	Published - 2022

Keywords

MTX-associated lymphoproliferative disorder
angioimmunoblastic T-cell lymphoma
methotrexate
plasmacytosis

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.8422-21

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title = "Angioimmunoblastic T-cell Lymphoma Presenting as a Methotrexate-associated Lymphoproliferative Disorder with Extreme Peripheral Blood Plasmacytosis",

abstract = "A 74-year-old man was admitted to our hospital because of systemic lymphadenopathy, weight loss, and a fever at night that had persisted for approximately 1 month. Blood tests revealed extreme peripheral blood plasmacytosis and hypergammaglobulinemia. A lymph node biopsy showed angioimmunoblastic T-cell lymphoma (AITL). Based on the history of methotrexate (MTX) administration, the established diagnosis was MTX-associated lymphoproliferative disorder (MTX-LPD). After MTX was discontinued, the lymphadenopathy spontaneously regressed and the plasmacytosis disappeared. He had no disease progression for three years. We found that AITL as an MTX-LPD can cause plasmacytosis, and the prognosis of this disease may not be poor.",

keywords = "MTX-associated lymphoproliferative disorder, angioimmunoblastic T-cell lymphoma, methotrexate, plasmacytosis",

author = "Hiroyuki Murakami and Masanori Makita and Tatsunori Ishikawa and Takanori Yoshioka and Keina Nagakita and Yoko Shinno and Tadashi Yoshino and Yoshinobu Maeda and Kazutaka Sunami",

note = "Publisher Copyright: {\textcopyright} 2022 The Japanese Society of Internal Medicine.",

year = "2022",

doi = "10.2169/internalmedicine.8422-21",

language = "English",

volume = "61",

pages = "2655--2660",

journal = "Internal Medicine",

issn = "0918-2918",

publisher = "Japanese Society of Internal Medicine",

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TY - JOUR

T1 - Angioimmunoblastic T-cell Lymphoma Presenting as a Methotrexate-associated Lymphoproliferative Disorder with Extreme Peripheral Blood Plasmacytosis

AU - Murakami, Hiroyuki

AU - Makita, Masanori

AU - Ishikawa, Tatsunori

AU - Yoshioka, Takanori

AU - Nagakita, Keina

AU - Shinno, Yoko

AU - Yoshino, Tadashi

AU - Maeda, Yoshinobu

AU - Sunami, Kazutaka

PY - 2022

Y1 - 2022

N2 - A 74-year-old man was admitted to our hospital because of systemic lymphadenopathy, weight loss, and a fever at night that had persisted for approximately 1 month. Blood tests revealed extreme peripheral blood plasmacytosis and hypergammaglobulinemia. A lymph node biopsy showed angioimmunoblastic T-cell lymphoma (AITL). Based on the history of methotrexate (MTX) administration, the established diagnosis was MTX-associated lymphoproliferative disorder (MTX-LPD). After MTX was discontinued, the lymphadenopathy spontaneously regressed and the plasmacytosis disappeared. He had no disease progression for three years. We found that AITL as an MTX-LPD can cause plasmacytosis, and the prognosis of this disease may not be poor.

AB - A 74-year-old man was admitted to our hospital because of systemic lymphadenopathy, weight loss, and a fever at night that had persisted for approximately 1 month. Blood tests revealed extreme peripheral blood plasmacytosis and hypergammaglobulinemia. A lymph node biopsy showed angioimmunoblastic T-cell lymphoma (AITL). Based on the history of methotrexate (MTX) administration, the established diagnosis was MTX-associated lymphoproliferative disorder (MTX-LPD). After MTX was discontinued, the lymphadenopathy spontaneously regressed and the plasmacytosis disappeared. He had no disease progression for three years. We found that AITL as an MTX-LPD can cause plasmacytosis, and the prognosis of this disease may not be poor.

KW - MTX-associated lymphoproliferative disorder

KW - angioimmunoblastic T-cell lymphoma

KW - methotrexate

KW - plasmacytosis

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AN - SCOPUS:85137138291

SN - 0918-2918

VL - 61

SP - 2655

EP - 2660

JO - Internal Medicine

JF - Internal Medicine

IS - 17

ER -

Angioimmunoblastic T-cell Lymphoma Presenting as a Methotrexate-associated Lymphoproliferative Disorder with Extreme Peripheral Blood Plasmacytosis

Abstract

Keywords

ASJC Scopus subject areas

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