Animal models for Parkinson’s disease research: Trends in the 2000s

Kyohei Kin, Takao Yasuhara, Masahiro Kameda, Isao Date

Research output: Contribution to journalReview articlepeer-review

86 Citations (Scopus)


Parkinson’s disease (PD) is a chronic and progressive movement disorder and the second most common neurodegenerative disease. Although many studies have been conducted, there is an unmet clinical need to develop new treatments because, currently, only symptomatic therapies are available. To achieve this goal, clarification of the pathology is required. Attempts have been made to emulate human PD and various animal models have been developed over the decades. Neurotoxin models have been commonly used for PD research. Recently, advances in transgenic technology have enabled the development of genetic models that help to identify new approaches in PD research. However, PD animal model trends have not been investigated. Revealing the trends for PD research will be valuable for increasing our understanding of the positive and negative aspects of each model. In this article, we clarified the trends for animal models that were used to research PD in the 2000s, and we discussed each model based on these trends.

Original languageEnglish
Article number5402
JournalInternational journal of molecular sciences
Issue number21
Publication statusPublished - Nov 1 2019


  • 1-methyl-4-phenyl-1
  • 2
  • 3
  • 6-hydroxydopamine
  • 6-tetrahydropyridine
  • Animal model
  • DJ-1
  • Neurotoxin
  • PINK1
  • Parkin
  • Parkinson’s disease
  • Pesticide
  • α-synuclein

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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