TY - JOUR
T1 - Anti-ageing effects of dentifrices containing anti-oxidative, anti-inflammatory, and anti-bacterial agents (Tomarina®) on gingival collagen degradation in rats
AU - Irie, Koichiro
AU - Tomofuji, Takaaki
AU - Ekuni, Daisuke
AU - Endo, Yasumasa
AU - Kasuyama, Kenta
AU - Azuma, Tetsuji
AU - Tamaki, Naofumi
AU - Yoneda, Toshiki
AU - Morita, Manabu
N1 - Funding Information:
This study was supported by Grants-in-Aid for Scientific Research (23390480 and 24593153) from the Ministry of Education, Culture, Sports, Science and Technology, Tokyo, Japan. The authors report no conflicts of interest related to this study.
PY - 2014
Y1 - 2014
N2 - Objective Previous studies have demonstrated the relationship between ageing and oxidative stress. In this study, we examined the effects of topical application of a dentifrice containing anti-oxidative, anti-inflammatory, and anti-bacterial agents (Tomarina®) to the gingival surface on gingival collagen degradation in rats. Design Fischer 344 male rats (4 or 8 months old) were divided into two groups: experimental group and control group. Tomarina® (the experimental group) or control dentifrice (the control group) was applied 5 days per week for 2 months. Results In the control group, gingival collagen density decreased with ageing. In the experimental group, the collagen density did not change with ageing, and was greater than that in the control group at 10 months of age (p < 0.0083). In addition, the control group showed an increase in serum oxidative stress with ageing. The experimental group also showed increased serum oxidative stress, but the value was lower than the control group at 10 months of age (p < 0.0083). Furthermore, low expressions of protein oxidative damage in the periodontal tissue were observed in the experimental group, compared to the control group at 6 months and 10 months. Conclusion These findings indicate that Tomarina ® might suppress the effects of ageing on gingival collagen degradation, by decreasing oxidative stress in the rat model.
AB - Objective Previous studies have demonstrated the relationship between ageing and oxidative stress. In this study, we examined the effects of topical application of a dentifrice containing anti-oxidative, anti-inflammatory, and anti-bacterial agents (Tomarina®) to the gingival surface on gingival collagen degradation in rats. Design Fischer 344 male rats (4 or 8 months old) were divided into two groups: experimental group and control group. Tomarina® (the experimental group) or control dentifrice (the control group) was applied 5 days per week for 2 months. Results In the control group, gingival collagen density decreased with ageing. In the experimental group, the collagen density did not change with ageing, and was greater than that in the control group at 10 months of age (p < 0.0083). In addition, the control group showed an increase in serum oxidative stress with ageing. The experimental group also showed increased serum oxidative stress, but the value was lower than the control group at 10 months of age (p < 0.0083). Furthermore, low expressions of protein oxidative damage in the periodontal tissue were observed in the experimental group, compared to the control group at 6 months and 10 months. Conclusion These findings indicate that Tomarina ® might suppress the effects of ageing on gingival collagen degradation, by decreasing oxidative stress in the rat model.
KW - Ageing
KW - Anti-oxidants
KW - Dentifrice
KW - Gingival collagen
KW - Oxidative stress
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U2 - 10.1016/j.archoralbio.2013.09.008
DO - 10.1016/j.archoralbio.2013.09.008
M3 - Article
C2 - 24404578
AN - SCOPUS:84888307856
SN - 0003-9969
VL - 59
SP - 60
EP - 65
JO - Archives of Oral Biology
JF - Archives of Oral Biology
IS - 1
ER -