Anti-methicillin resistant Staphylococcus aureus (MRSA) compounds isolated from Laurus nobilis

Nao Otsuka, Mei Hua Liu, Sumiko Shiota, Wakano Ogawa, Teruo Kuroda, Tsutomu Hatano, Tomofusa Tsuchiya

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)


We found that an extract from Laurus nobilis L. (Lauraceae) leaves showed antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). We purified two flavonoids as the effective compounds and identified them as kaempferol 3-O-α-L-(2″,4″-di-E-p-coumaroyl)-rhamnoside (C2) and kaempferol 3-O-α-L-(2″-Z-p-coumaroyl-4″-E-p- coumaroyl)-rhamnoside (C3). Both compounds showed strong antibacterial activity not only against MRSA but also against vancomycin-resistant enterococci (VRE). There was low or no antibacterial activity of C2 and C3 for Streptococcus pneumoniae, Pseudomonas aeruginosa and Serratia marcescens.

Original languageEnglish
Pages (from-to)1794-1797
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Issue number9
Publication statusPublished - Sept 2008


  • Anti-methicillin-resistant Staphylococcus aureus compound
  • Anti-vancomycin-resistant enterococci
  • Laurus nobilis
  • Methicillin-resistant Staphylococcus aureus
  • Vancomycin-resistant enterococci

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science


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