Anti-musk antibody-positive myasthenia gravis successfully treated with outpatient periodic weekly blood purification therapy

Kentaro Deguchi; Kosuke Matsuzono; Yumiko Nakano; Syoichiro Kono; Kota Sato; Shoko Deguchi; Katsuyuki Tanabe; Nozomi Hishikawa; Yasuyuki Ohta; Toru Yamashita; Kiyoe Ohta; Masakatsu Motomura; Koji Abe

doi:10.2169/internalmedicine.9466-17

Anti-musk antibody-positive myasthenia gravis successfully treated with outpatient periodic weekly blood purification therapy

Kentaro Deguchi, Kosuke Matsuzono, Yumiko Nakano, Syoichiro Kono, Kota Sato, Shoko Deguchi, Katsuyuki Tanabe, Nozomi Hishikawa, Yasuyuki Ohta, Toru Yamashita, Kiyoe Ohta, Masakatsu Motomura, Koji Abe

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A 37-year-old man with anti-muscle-specific tyrosine kinase (MuSK) antibody-positive myasthenia gravis (MG) presented with subacute progressive dysphagia and muscle weakness of the neck and bilateral upper extremities. Conventional immune-suppressive treatments and high-dose intravenous immunoglobulin were ineffective. He then displayed repeated exacerbations and remissions over the course of two years, despite two to four sessions of plasma exchange (PE) every two months. The patient was successfully treated with outpatient periodic weekly blood purification therapy with alternative PE and double-filtration plasmapheresis using an internal shunt. This case report suggests the benefits of blood purification therapy with an internal shunt against anti-MuSK antibody-positive MG.

Original language	English
Pages (from-to)	1455-1458
Number of pages	4
Journal	Internal Medicine
Volume	57
Issue number	10
DOIs	https://doi.org/10.2169/internalmedicine.9466-17
Publication status	Published - 2018

Keywords

Anti-MuSK antibodies
Myasthenia gravis
Periodic weekly blood purification therapy

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.9466-17

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Deguchi, K., Matsuzono, K., Nakano, Y., Kono, S., Sato, K., Deguchi, S., Tanabe, K., Hishikawa, N., Ohta, Y., Yamashita, T., Ohta, K., Motomura, M., & Abe, K. (2018). Anti-musk antibody-positive myasthenia gravis successfully treated with outpatient periodic weekly blood purification therapy. Internal Medicine, 57(10), 1455-1458. https://doi.org/10.2169/internalmedicine.9466-17

Deguchi, K, Matsuzono, K, Nakano, Y, Kono, S, Sato, K, Deguchi, S, Tanabe, K, Hishikawa, N, Ohta, Y, Yamashita, T, Ohta, K, Motomura, M & Abe, K 2018, 'Anti-musk antibody-positive myasthenia gravis successfully treated with outpatient periodic weekly blood purification therapy', Internal Medicine, vol. 57, no. 10, pp. 1455-1458. https://doi.org/10.2169/internalmedicine.9466-17

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title = "Anti-musk antibody-positive myasthenia gravis successfully treated with outpatient periodic weekly blood purification therapy",

abstract = "A 37-year-old man with anti-muscle-specific tyrosine kinase (MuSK) antibody-positive myasthenia gravis (MG) presented with subacute progressive dysphagia and muscle weakness of the neck and bilateral upper extremities. Conventional immune-suppressive treatments and high-dose intravenous immunoglobulin were ineffective. He then displayed repeated exacerbations and remissions over the course of two years, despite two to four sessions of plasma exchange (PE) every two months. The patient was successfully treated with outpatient periodic weekly blood purification therapy with alternative PE and double-filtration plasmapheresis using an internal shunt. This case report suggests the benefits of blood purification therapy with an internal shunt against anti-MuSK antibody-positive MG.",

keywords = "Anti-MuSK antibodies, Myasthenia gravis, Periodic weekly blood purification therapy",

author = "Kentaro Deguchi and Kosuke Matsuzono and Yumiko Nakano and Syoichiro Kono and Kota Sato and Shoko Deguchi and Katsuyuki Tanabe and Nozomi Hishikawa and Yasuyuki Ohta and Toru Yamashita and Kiyoe Ohta and Masakatsu Motomura and Koji Abe",

note = "Funding Information: This work was partly supported by a Grant-in-Aid for Scientific Research (B) 2529320216, (C) 24591263 and Challenging Research 24659651, and by Grants-in-Aid from the Research Committees (Mizusawa H, Nakashima K, Nishizawa M, Sasaki H, and Aoki M) from the Ministry of Health, Labour, and Welfare of Japan. Publisher Copyright: {\textcopyright} 2018 The Japanese Society of Internal Medicine.",

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doi = "10.2169/internalmedicine.9466-17",

language = "English",

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T1 - Anti-musk antibody-positive myasthenia gravis successfully treated with outpatient periodic weekly blood purification therapy

AU - Deguchi, Kentaro

AU - Matsuzono, Kosuke

AU - Nakano, Yumiko

AU - Kono, Syoichiro

AU - Sato, Kota

AU - Deguchi, Shoko

AU - Tanabe, Katsuyuki

AU - Hishikawa, Nozomi

AU - Ohta, Yasuyuki

AU - Yamashita, Toru

AU - Ohta, Kiyoe

AU - Motomura, Masakatsu

AU - Abe, Koji

N1 - Funding Information: This work was partly supported by a Grant-in-Aid for Scientific Research (B) 2529320216, (C) 24591263 and Challenging Research 24659651, and by Grants-in-Aid from the Research Committees (Mizusawa H, Nakashima K, Nishizawa M, Sasaki H, and Aoki M) from the Ministry of Health, Labour, and Welfare of Japan. Publisher Copyright: © 2018 The Japanese Society of Internal Medicine.

PY - 2018

Y1 - 2018

N2 - A 37-year-old man with anti-muscle-specific tyrosine kinase (MuSK) antibody-positive myasthenia gravis (MG) presented with subacute progressive dysphagia and muscle weakness of the neck and bilateral upper extremities. Conventional immune-suppressive treatments and high-dose intravenous immunoglobulin were ineffective. He then displayed repeated exacerbations and remissions over the course of two years, despite two to four sessions of plasma exchange (PE) every two months. The patient was successfully treated with outpatient periodic weekly blood purification therapy with alternative PE and double-filtration plasmapheresis using an internal shunt. This case report suggests the benefits of blood purification therapy with an internal shunt against anti-MuSK antibody-positive MG.

AB - A 37-year-old man with anti-muscle-specific tyrosine kinase (MuSK) antibody-positive myasthenia gravis (MG) presented with subacute progressive dysphagia and muscle weakness of the neck and bilateral upper extremities. Conventional immune-suppressive treatments and high-dose intravenous immunoglobulin were ineffective. He then displayed repeated exacerbations and remissions over the course of two years, despite two to four sessions of plasma exchange (PE) every two months. The patient was successfully treated with outpatient periodic weekly blood purification therapy with alternative PE and double-filtration plasmapheresis using an internal shunt. This case report suggests the benefits of blood purification therapy with an internal shunt against anti-MuSK antibody-positive MG.

KW - Anti-MuSK antibodies

KW - Myasthenia gravis

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Anti-musk antibody-positive myasthenia gravis successfully treated with outpatient periodic weekly blood purification therapy

Abstract

Keywords

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