Anti-tumor and immunoregulatory effects of fermented papaya preparation (FPP: SAIDO-PS501)

Shinki Murakami, Shingo Eikawa, Savas Kaya, Mitsuko Imao, Toshiki Aji

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Various beneficial effects have been described for fermented papaya preparation (FPP: SAIDO-PS501) based on its anti-oxidative and anti-inflammatory functions. The present study was designed to determine the effects of FPP on carcinogenesis in vivo, and immunomodulatory function in vitro. Mice were injected with RL male 1 cells subcutaneously or 3-methylcholantherene (MCA) intravenously to induce cancer and orally or intraperitoneally treated with FPP solution. Human peripheral blood mononuclear cells (PBMC) were obtained from healthy volunteers and patients with atopic dermatitis, treated with FPP, and subjected to measurement of cytokine production and changes in Foxp3-expressing regulatory T cell (Treg) stimulated with phytohemagglutinin (PHA). Administration of FPP suppressed tumor size and the incidence of malignancy. In vitro, treatment of PBMC with FPP induced IL-1ß, TNFα and IFNγ production. Moreover, FPP suppressed proliferation of PHA-stimulated Foxp3-expressing Treg. These results suggest that FPP has chemotherapeutic properties.

Original languageEnglish
Pages (from-to)3077-3084
Number of pages8
JournalAsian Pacific Journal of Cancer Prevention
Issue number7
Publication statusPublished - 2016


  • Anti-tumorigenesis
  • Fermented papaya preparation
  • Immunoregulatory function
  • Interferonγ
  • Regulatory

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research


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