Antibody Response to Oral Streptococci in Behcet's Disease

Kenji Yokota, Syunii Hayashi, Nobuhiro Fujii, Kouji Yoshikawa, Satoshi Kotake, Emiko Isogai, Shigeaki Ohno, Yoshio Araki, Keiji Oguma

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48 Citations (Scopus)


The serum antibody titers against oral streptococci were studied by enzyme-linked immunosorbent assay (ELISA) both in patients with Behcet's disease (BD) and control groups. The patients with BD showed significantly higher antibody titers to S. sanguis strains 113–20, 114–23, and 118–1 which were isolated from patients with BD, in comparison with control groups. Also, the reactions of high-titered sera to the crude cell wall and soluble (or membrane) fractions of the 113–20 strain were observed by western blot test. The sera of the patients with BD demonstrated strong bands of approximately 36 kDa, 82 kDa, and 87 kDa in the crude cell wall fractions, and many bands of 80 kDa to 150 kDa in the membrane fractions, indicating that these proteins are the ones leading the high antibody titers to this bacterium in the sera of patients with BD.

Original languageEnglish
Pages (from-to)815-822
Number of pages8
Issue number8
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology


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