Anticarcinogenic Activities of Polyphenols in Foods and Herbs

Ken Ichi Miyamoto, Tsugiya Murayama, Takashi Yoshida, Tsutomu Hatano, Takuo Okuda

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


The host-mediated anticancer activity, which is an anticarcinogenic activity found for polyphenols besides the inhibition of mutagenicity and tumor-promotion, is specific to some oligomeric hydrolyzable tannins. Agrimoniin, a dimer isolated from Agrimonia pilosa which is used as a herbal medicine and vegetable, was the first oligomer of this type. The macro cyclic ellagitannin dimer, such as oenothein B, often showed this activity, which was also found for some trimers and tetramers. These tannins stimulated macrophage in vitro and in vivo, resulting in inducation of interleukin-1 and increase of cytotoxic immunocytes. The anticancer activity is attributable to potential of the host-mediated defence via activation of macrophage.

Original languageEnglish
Pages (from-to)245-259
Number of pages15
JournalACS Symposium Series
Publication statusPublished - Dec 1 1997

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)


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