Antidepressant-like effect of 1α-hydroxyvitamin D3 on mice in the forced swimming test

Akihiko Kawaura; Yoshihisa Kitamura; Noritoshi Tanida; Junichi Akiyama; Masatoshi Mizutani; Kazuhiro Harada; Motoyoshi Morishita; Shigeki Inoue; Yoshio Kano; Toshio Okano; Eiji Takeda

doi:10.3177/jnsv.63.81

Antidepressant-like effect of 1α-hydroxyvitamin D₃ on mice in the forced swimming test

Akihiko Kawaura, Yoshihisa Kitamura, Noritoshi Tanida, Junichi Akiyama, Masatoshi Mizutani, Kazuhiro Harada, Motoyoshi Morishita, Shigeki Inoue, Yoshio Kano, Toshio Okano, Eiji Takeda

University Hospital

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

We examined the effect of 1α-hydroxyvitamin D₃ [1α(OH)D₃] on mice in the forced swimming test. Intragastric administration of 1.0 μg/kg of 1α(OH)D₃ reduced immobility time in the forced swimming test. At all concentrations tested (0.5, 1.0, 2.0 μg/kg), 1α(OH)D₃ had no effect on locomotor activity, compared with controls. These results suggest that 1α(OH)D₃ may have antidepressant-like activity.

Original language	English
Pages (from-to)	81-84
Number of pages	4
Journal	Journal of Nutritional Science and Vitaminology
Volume	63
Issue number	1
DOIs	https://doi.org/10.3177/jnsv.63.81
Publication status	Published - 2017

Keywords

1α-hydroxyvitamin D
Brain-derived neurotrophic factor
Forced swimming test
Glial cell line–derived neurotrophic factor

ASJC Scopus subject areas

Medicine (miscellaneous)
Nutrition and Dietetics

Access to Document

10.3177/jnsv.63.81

Cite this

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title = "Antidepressant-like effect of 1α-hydroxyvitamin D3 on mice in the forced swimming test",

abstract = "We examined the effect of 1α-hydroxyvitamin D3 [1α(OH)D3] on mice in the forced swimming test. Intragastric administration of 1.0 μg/kg of 1α(OH)D3 reduced immobility time in the forced swimming test. At all concentrations tested (0.5, 1.0, 2.0 μg/kg), 1α(OH)D3 had no effect on locomotor activity, compared with controls. These results suggest that 1α(OH)D3 may have antidepressant-like activity.",

keywords = "1α-hydroxyvitamin D, Brain-derived neurotrophic factor, Forced swimming test, Glial cell line–derived neurotrophic factor",

author = "Akihiko Kawaura and Yoshihisa Kitamura and Noritoshi Tanida and Junichi Akiyama and Masatoshi Mizutani and Kazuhiro Harada and Motoyoshi Morishita and Shigeki Inoue and Yoshio Kano and Toshio Okano and Eiji Takeda",

note = "Funding Information: This work was supported by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (Incorporated Administrative Agency). Chugai Laboratories and Mitsuba Trading Co., Ltd., supplied 1?(OH)D3 and MCT, respectively, but were not involved in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2017, Center for Academic Publications Japan. All rights reserved.",

year = "2017",

doi = "10.3177/jnsv.63.81",

language = "English",

volume = "63",

pages = "81--84",

journal = "Journal of Nutritional Science and Vitaminology",

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AU - Kawaura, Akihiko

AU - Kitamura, Yoshihisa

AU - Tanida, Noritoshi

AU - Akiyama, Junichi

AU - Mizutani, Masatoshi

AU - Harada, Kazuhiro

AU - Morishita, Motoyoshi

AU - Inoue, Shigeki

AU - Kano, Yoshio

AU - Okano, Toshio

AU - Takeda, Eiji

N1 - Funding Information: This work was supported by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (Incorporated Administrative Agency). Chugai Laboratories and Mitsuba Trading Co., Ltd., supplied 1?(OH)D3 and MCT, respectively, but were not involved in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2017, Center for Academic Publications Japan. All rights reserved.

PY - 2017

Y1 - 2017

N2 - We examined the effect of 1α-hydroxyvitamin D3 [1α(OH)D3] on mice in the forced swimming test. Intragastric administration of 1.0 μg/kg of 1α(OH)D3 reduced immobility time in the forced swimming test. At all concentrations tested (0.5, 1.0, 2.0 μg/kg), 1α(OH)D3 had no effect on locomotor activity, compared with controls. These results suggest that 1α(OH)D3 may have antidepressant-like activity.

AB - We examined the effect of 1α-hydroxyvitamin D3 [1α(OH)D3] on mice in the forced swimming test. Intragastric administration of 1.0 μg/kg of 1α(OH)D3 reduced immobility time in the forced swimming test. At all concentrations tested (0.5, 1.0, 2.0 μg/kg), 1α(OH)D3 had no effect on locomotor activity, compared with controls. These results suggest that 1α(OH)D3 may have antidepressant-like activity.

KW - 1α-hydroxyvitamin D

KW - Brain-derived neurotrophic factor

KW - Forced swimming test

KW - Glial cell line–derived neurotrophic factor

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