Antihepatotoxic actions of tannins

Hikino Hiroshi; Kiso Yoshinobu; Hatano Tsutomu; Yoshida Takashi; Okuda Takuo

doi:10.1016/0378-8741(85)90024-8

Antihepatotoxic actions of tannins

Hikino Hiroshi, Kiso Yoshinobu, Hatano Tsutomu, Yoshida Takashi, Okuda Takuo

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The antihepatotoxic effects of tannin analogues were examined utilizing carbon tetrachloride- and galactosamine-induced cytotoxicity in primary cultured rat hepatocytes. Most tannins showed significant antihepatotoxic effects in these two assay systems. Hydrolyzable tannins generally exhibited an intense enzyme inhibitory action on glutamic-pyruvic transaminase while condensed tannins exerted a much less inhibitory action, although variations were observed depending on structure. Structure-activity relationships are discussed.

Original language	English
Pages (from-to)	19-29
Number of pages	11
Journal	Journal of Ethnopharmacology
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/0378-8741(85)90024-8
Publication status	Published - Sept 1985

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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author = "Hikino Hiroshi and Kiso Yoshinobu and Hatano Tsutomu and Yoshida Takashi and Okuda Takuo",

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AU - Hiroshi, Hikino

AU - Yoshinobu, Kiso

AU - Tsutomu, Hatano

AU - Takashi, Yoshida

AU - Takuo, Okuda

PY - 1985/9

Y1 - 1985/9

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AB - The antihepatotoxic effects of tannin analogues were examined utilizing carbon tetrachloride- and galactosamine-induced cytotoxicity in primary cultured rat hepatocytes. Most tannins showed significant antihepatotoxic effects in these two assay systems. Hydrolyzable tannins generally exhibited an intense enzyme inhibitory action on glutamic-pyruvic transaminase while condensed tannins exerted a much less inhibitory action, although variations were observed depending on structure. Structure-activity relationships are discussed.

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Antihepatotoxic actions of tannins

Abstract

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