Antimalarial activities in vitro of homoprotoberberine derivatives. Design of novel antimalarials and structure-activity relationship analysis

Junji Miyata; Hiromi Nakashima; Hideo Nemoto; Hye Sook Kim; Yusuke Wataya; Masataka Ihara

doi:10.3987/com-98-s46

Antimalarial activities in vitro of homoprotoberberine derivatives. Design of novel antimalarials and structure-activity relationship analysis

Junji Miyata, Hiromi Nakashima, Hideo Nemoto, Hye Sook Kim, Yusuke Wataya, Masataka Ihara

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Antimalarial activities in vitro of homoprotoberberine derivatives against Plasmodium falciparum were examined. It has shown that 9-hydroxy- 2,3,10-trimethoxyhomoprotoberberine (10) was the most potent compound and the hydroxyl group at the C-9 position would play a significant role in exhibiting antimalarial activity and selective toxicity.

Original language	English
Pages (from-to)	101-104
Number of pages	4
Journal	Heterocycles
Volume	49
Issue number	1
DOIs	https://doi.org/10.3987/com-98-s46
Publication status	Published - Dec 31 1998

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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abstract = "Antimalarial activities in vitro of homoprotoberberine derivatives against Plasmodium falciparum were examined. It has shown that 9-hydroxy- 2,3,10-trimethoxyhomoprotoberberine (10) was the most potent compound and the hydroxyl group at the C-9 position would play a significant role in exhibiting antimalarial activity and selective toxicity.",

author = "Junji Miyata and Hiromi Nakashima and Hideo Nemoto and Kim, {Hye Sook} and Yusuke Wataya and Masataka Ihara",

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AU - Nemoto, Hideo

AU - Kim, Hye Sook

AU - Wataya, Yusuke

AU - Ihara, Masataka

PY - 1998/12/31

Y1 - 1998/12/31

N2 - Antimalarial activities in vitro of homoprotoberberine derivatives against Plasmodium falciparum were examined. It has shown that 9-hydroxy- 2,3,10-trimethoxyhomoprotoberberine (10) was the most potent compound and the hydroxyl group at the C-9 position would play a significant role in exhibiting antimalarial activity and selective toxicity.

AB - Antimalarial activities in vitro of homoprotoberberine derivatives against Plasmodium falciparum were examined. It has shown that 9-hydroxy- 2,3,10-trimethoxyhomoprotoberberine (10) was the most potent compound and the hydroxyl group at the C-9 position would play a significant role in exhibiting antimalarial activity and selective toxicity.

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Antimalarial activities in vitro of homoprotoberberine derivatives. Design of novel antimalarials and structure-activity relationship analysis

Abstract

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