Antimalarial activity and nucleoside transport inhibitory activity of the triterpenic constituents of Cimicifuga spp.

Masayuki Takahara; Akiko Kusano; Makio Shibano; Genjiro Kusano; Kenzo Koizumi; Ryuji Suzuki; Hye Sook Kim; Yusuke Wataya

doi:10.1248/bpb.21.823

Antimalarial activity and nucleoside transport inhibitory activity of the triterpenic constituents of Cimicifuga spp.

Masayuki Takahara, Akiko Kusano, Makio Shibano, Genjiro Kusano, Kenzo Koizumi, Ryuji Suzuki, Hye Sook Kim, Yusuke Wataya

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

The in vitro antimalarial activity against human malaria parasite (Plasmodium falciparum, FCR-3 strain) was examined using 59 triterpenoids obtained during studies on the triterpenic constituents of Cimicifuga spp. The 50% effective concentration values (EC₅₀) of 25 active triterpenoids were 1.0-3.0 μM, and 19 of the compounds had a common 16, 23 : 23, 26 : 24, 25-triepoxy group in the side-chain moieties. Among the active triterpenoids, 9 also showed significant inhibition of nucleoside transport in mouse splenocytes. A relationship between the antimalarial activity and the inhibition of nucleoside transport involving these triterpenoids is discussed.

Original language	English
Pages (from-to)	823-828
Number of pages	6
Journal	Biological and Pharmaceutical Bulletin
Volume	21
Issue number	8
DOIs	https://doi.org/10.1248/bpb.21.823
Publication status	Published - 1998

Keywords

9,19-cyclolanostane glycoside
Antimalarial activity
Cimicifuga
Nucleoside transport inhibition
Ranunculaceae
Thymidine-H uptake

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1248/bpb.21.823

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title = "Antimalarial activity and nucleoside transport inhibitory activity of the triterpenic constituents of Cimicifuga spp.",

abstract = "The in vitro antimalarial activity against human malaria parasite (Plasmodium falciparum, FCR-3 strain) was examined using 59 triterpenoids obtained during studies on the triterpenic constituents of Cimicifuga spp. The 50% effective concentration values (EC50) of 25 active triterpenoids were 1.0-3.0 μM, and 19 of the compounds had a common 16, 23 : 23, 26 : 24, 25-triepoxy group in the side-chain moieties. Among the active triterpenoids, 9 also showed significant inhibition of nucleoside transport in mouse splenocytes. A relationship between the antimalarial activity and the inhibition of nucleoside transport involving these triterpenoids is discussed.",

keywords = "9,19-cyclolanostane glycoside, Antimalarial activity, Cimicifuga, Nucleoside transport inhibition, Ranunculaceae, Thymidine-H uptake",

author = "Masayuki Takahara and Akiko Kusano and Makio Shibano and Genjiro Kusano and Kenzo Koizumi and Ryuji Suzuki and Kim, {Hye Sook} and Yusuke Wataya",

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language = "English",

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T1 - Antimalarial activity and nucleoside transport inhibitory activity of the triterpenic constituents of Cimicifuga spp.

AU - Takahara, Masayuki

AU - Kusano, Akiko

AU - Shibano, Makio

AU - Kusano, Genjiro

AU - Koizumi, Kenzo

AU - Suzuki, Ryuji

AU - Kim, Hye Sook

AU - Wataya, Yusuke

PY - 1998

Y1 - 1998

N2 - The in vitro antimalarial activity against human malaria parasite (Plasmodium falciparum, FCR-3 strain) was examined using 59 triterpenoids obtained during studies on the triterpenic constituents of Cimicifuga spp. The 50% effective concentration values (EC50) of 25 active triterpenoids were 1.0-3.0 μM, and 19 of the compounds had a common 16, 23 : 23, 26 : 24, 25-triepoxy group in the side-chain moieties. Among the active triterpenoids, 9 also showed significant inhibition of nucleoside transport in mouse splenocytes. A relationship between the antimalarial activity and the inhibition of nucleoside transport involving these triterpenoids is discussed.

AB - The in vitro antimalarial activity against human malaria parasite (Plasmodium falciparum, FCR-3 strain) was examined using 59 triterpenoids obtained during studies on the triterpenic constituents of Cimicifuga spp. The 50% effective concentration values (EC50) of 25 active triterpenoids were 1.0-3.0 μM, and 19 of the compounds had a common 16, 23 : 23, 26 : 24, 25-triepoxy group in the side-chain moieties. Among the active triterpenoids, 9 also showed significant inhibition of nucleoside transport in mouse splenocytes. A relationship between the antimalarial activity and the inhibition of nucleoside transport involving these triterpenoids is discussed.

KW - 9,19-cyclolanostane glycoside

KW - Antimalarial activity

KW - Cimicifuga

KW - Nucleoside transport inhibition

KW - Ranunculaceae

KW - Thymidine-H uptake

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DO - 10.1248/bpb.21.823

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SN - 0918-6158

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JO - Biological and Pharmaceutical Bulletin

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ER -

Antimalarial activity and nucleoside transport inhibitory activity of the triterpenic constituents of Cimicifuga spp.

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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