Antimalarial activity of lavandulyl flavanones isolated from the roots of Sophora flavescens

Youn Chul Kim; Hye Sook Kim; Yusuke Wataya; Dong Hwan Sohn; Tai Hyun Kang; Myung Soo Kim; Yong Man Kim; Geon Mok Lee; Jong Duk Chang; Hyun Park

doi:10.1248/bpb.27.748

Antimalarial activity of lavandulyl flavanones isolated from the roots of Sophora flavescens

Youn Chul Kim, Hye Sook Kim, Yusuke Wataya, Dong Hwan Sohn, Tai Hyun Kang, Myung Soo Kim, Yong Man Kim, Geon Mok Lee, Jong Duk Chang, Hyun Park

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Four lavandulyl flavanones, (2S)-2′-methoxykurarinone (1), sophoraflavanone G (2), leachianone A (3), and (-)-kurarinone (4), which are isolated from the roots of Sophora flavescens have been tested for in vitro antimalarial activity against Plasmodium falciparum. Compounds 1-3 showed moderate antimalarial activities with EC₅₀ values of 2.4×10^-6, 2.6×10^-6, and 2.1×10 ^-6M, respectively. These compounds did not show selective toxicity against P. falciparum in the toxicity test on mouse mammalian tumor cells, however, it is suggested that the position of methoxyl groups in flavanone skeleton plays an important role on antimalarial activity.

Original language	English
Pages (from-to)	748-750
Number of pages	3
Journal	Biological and Pharmaceutical Bulletin
Volume	27
Issue number	5
DOIs	https://doi.org/10.1248/bpb.27.748
Publication status	Published - May 2004

Keywords

Antimalarial
Lavandulyl flavanone
Plasmodium falciparum
Sophora flavescens

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

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title = "Antimalarial activity of lavandulyl flavanones isolated from the roots of Sophora flavescens",

abstract = "Four lavandulyl flavanones, (2S)-2′-methoxykurarinone (1), sophoraflavanone G (2), leachianone A (3), and (-)-kurarinone (4), which are isolated from the roots of Sophora flavescens have been tested for in vitro antimalarial activity against Plasmodium falciparum. Compounds 1-3 showed moderate antimalarial activities with EC50 values of 2.4×10-6, 2.6×10-6, and 2.1×10 -6M, respectively. These compounds did not show selective toxicity against P. falciparum in the toxicity test on mouse mammalian tumor cells, however, it is suggested that the position of methoxyl groups in flavanone skeleton plays an important role on antimalarial activity.",

keywords = "Antimalarial, Lavandulyl flavanone, Plasmodium falciparum, Sophora flavescens",

author = "Kim, {Youn Chul} and Kim, {Hye Sook} and Yusuke Wataya and Sohn, {Dong Hwan} and Kang, {Tai Hyun} and Kim, {Myung Soo} and Kim, {Yong Man} and Lee, {Geon Mok} and Chang, {Jong Duk} and Hyun Park",

year = "2004",

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doi = "10.1248/bpb.27.748",

language = "English",

volume = "27",

pages = "748--750",

journal = "Biological and Pharmaceutical Bulletin",

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AU - Kim, Youn Chul

AU - Kim, Hye Sook

AU - Wataya, Yusuke

AU - Sohn, Dong Hwan

AU - Kang, Tai Hyun

AU - Kim, Myung Soo

AU - Kim, Yong Man

AU - Lee, Geon Mok

AU - Chang, Jong Duk

AU - Park, Hyun

PY - 2004/5

Y1 - 2004/5

N2 - Four lavandulyl flavanones, (2S)-2′-methoxykurarinone (1), sophoraflavanone G (2), leachianone A (3), and (-)-kurarinone (4), which are isolated from the roots of Sophora flavescens have been tested for in vitro antimalarial activity against Plasmodium falciparum. Compounds 1-3 showed moderate antimalarial activities with EC50 values of 2.4×10-6, 2.6×10-6, and 2.1×10 -6M, respectively. These compounds did not show selective toxicity against P. falciparum in the toxicity test on mouse mammalian tumor cells, however, it is suggested that the position of methoxyl groups in flavanone skeleton plays an important role on antimalarial activity.

AB - Four lavandulyl flavanones, (2S)-2′-methoxykurarinone (1), sophoraflavanone G (2), leachianone A (3), and (-)-kurarinone (4), which are isolated from the roots of Sophora flavescens have been tested for in vitro antimalarial activity against Plasmodium falciparum. Compounds 1-3 showed moderate antimalarial activities with EC50 values of 2.4×10-6, 2.6×10-6, and 2.1×10 -6M, respectively. These compounds did not show selective toxicity against P. falciparum in the toxicity test on mouse mammalian tumor cells, however, it is suggested that the position of methoxyl groups in flavanone skeleton plays an important role on antimalarial activity.

KW - Antimalarial

KW - Lavandulyl flavanone

KW - Plasmodium falciparum

KW - Sophora flavescens

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Antimalarial activity of lavandulyl flavanones isolated from the roots of Sophora flavescens

Abstract

Keywords

ASJC Scopus subject areas

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