TY - JOUR
T1 - Antimicrobial susceptibility and molecular characteristics of 857 methicillin-resistant Staphylococcus aureus isolates from 16 medical centers in Japan (2008-2009)
T2 - Nationwide survey of community-acquired and nosocomial MRSA
AU - Yanagihara, Katsunori
AU - Araki, Nobuko
AU - Watanabe, Shinichi
AU - Kinebuchi, Takahiro
AU - Kaku, Mitsuo
AU - Maesaki, Shigefumi
AU - Yamaguchi, Keizo
AU - Matsumoto, Tetsuya
AU - Mikamo, Hiroshige
AU - Takesue, Yoshio
AU - Kadota, Jun Ichi
AU - Fujita, Jiro
AU - Iwatsuki, Keiji
AU - Hino, Haruko
AU - Kaneko, Takehiko
AU - Asagoe, Kenji
AU - Ikeda, Masami
AU - Yasuoka, Akira
AU - Kohno, Shigeru
PY - 2012/3
Y1 - 2012/3
N2 - This study is a nationwide survey of all clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates, including community-acquired MRSA (CA-MRSA), in Japan. A total of 857 MRSA clinical isolates were collected from the 16 institutions throughout Japan that participated in the survey (2008-2009). The drug susceptibility and staphylococcal cassette chromosome mec (SCC. mec) typing and the presence of specific pathogenic genes were evaluated. The isolates comprised SCC. mec type II (73.6%), type IV (20%), and type I (6%). The percentage of SCC. mec type IV isolates was significantly higher in outpatients than in inpatients. Most of the isolated strains were sensitive to vancomycin (VCM, MIC ≤2 μg/mL), linezolid (MIC ≤4 μg/mL), and teicoplanin (MIC ≤8 μg/mL). Although most strains were sensitive to VCM, the MIC value of VCM for SCC. mec type II strains was higher than that for SCC. mec type IV strains. Only 4 (2.3%) of 171 SCC. mec type IV strains were Panton-Valentine leukocidin (lukS/F-PV)-positive. Thus, this result indicates a unique feature of SCC. mec type IV strains in Japan. The information in this study not only is important in terms of local public health but will also contribute to an understanding of epidemic clones of CA-MRSA.
AB - This study is a nationwide survey of all clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates, including community-acquired MRSA (CA-MRSA), in Japan. A total of 857 MRSA clinical isolates were collected from the 16 institutions throughout Japan that participated in the survey (2008-2009). The drug susceptibility and staphylococcal cassette chromosome mec (SCC. mec) typing and the presence of specific pathogenic genes were evaluated. The isolates comprised SCC. mec type II (73.6%), type IV (20%), and type I (6%). The percentage of SCC. mec type IV isolates was significantly higher in outpatients than in inpatients. Most of the isolated strains were sensitive to vancomycin (VCM, MIC ≤2 μg/mL), linezolid (MIC ≤4 μg/mL), and teicoplanin (MIC ≤8 μg/mL). Although most strains were sensitive to VCM, the MIC value of VCM for SCC. mec type II strains was higher than that for SCC. mec type IV strains. Only 4 (2.3%) of 171 SCC. mec type IV strains were Panton-Valentine leukocidin (lukS/F-PV)-positive. Thus, this result indicates a unique feature of SCC. mec type IV strains in Japan. The information in this study not only is important in terms of local public health but will also contribute to an understanding of epidemic clones of CA-MRSA.
KW - Antimicrobial susceptibility
KW - CA-MRSA
KW - MRSA
KW - Molecular characteristic
KW - Nationwide survey
UR - http://www.scopus.com/inward/record.url?scp=84856608437&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856608437&partnerID=8YFLogxK
U2 - 10.1016/j.diagmicrobio.2011.11.010
DO - 10.1016/j.diagmicrobio.2011.11.010
M3 - Article
C2 - 22244779
AN - SCOPUS:84856608437
SN - 0732-8893
VL - 72
SP - 253
EP - 257
JO - Diagnostic Microbiology and Infectious Disease
JF - Diagnostic Microbiology and Infectious Disease
IS - 3
ER -
