TY - JOUR
T1 - Antimicrobial susceptibility of clinical isolates of aerobic gram-negative bacteria in 2006
AU - Yoshida, Isamu
AU - Yamaguchi, Takahiro
AU - Itoh, Yoshihisa
AU - Tachibana, Mineji
AU - Takahashi, Choichiro
AU - Kaku, Mitsuo
AU - Kanemitsu, Keiji
AU - Okada, Masahiko
AU - Horikawa, Yoshinori
AU - Shiotani, Joji
AU - Kino, Hiroyoshi
AU - Ono, Yuka
AU - Baba, Hisashi
AU - Matsuo, Shuji
AU - Asari, Seishi
AU - Toyokawa, Masahiro
AU - Matsuoka, Kimiko
AU - Kusano, Nobuchika
AU - Nose, Motoko
AU - Murase, Mitsuharu
AU - Miyamoto, Hitoshi
AU - Saikawa, Tetsunori
AU - Hiramatsu, Kazufumi
AU - Kohno, Shigeru
AU - Yanagihara, Katsunori
AU - Yamane, Nobuhisa
AU - Nakasone, Isamu
AU - Maki, Hideki
AU - Yamano, Yoshinori
PY - 2010/12
Y1 - 2010/12
N2 - We determined MICs of antibacterial agents against 1280 clinical strains of aerobic Gram-negative bacteria (19 genus or species) isolated at 16 Japanese facilities in 2006. MICs were determined using mostly broth microdilution method and antibacterial activity was assessed. Strains producing extended-spectrum β-lactamases (ESBL) accounted for 3.7% of Escherichia coli, 2.7% of Klebsiella spp., and 11.4% of Proteus spp. Notably, 18.8% of Proteus mirabilis was found to produce ESBL higher than 16.7% in 2004. This result was higher extremely than other species. Among Haemophilus influenzae, only 1.2% produced β-lactamase and 62.8% that increased compared with 57.7% in 2004, were β-lactamase-negative ampicillin-resistant strains when classified by penicillin-binding protein 3 mutation. Although few antibacterial agents against Pseudomonas aeruginosa have potent activity, only three agents - doripenem, ciprofloxacin, and tobramycin - showed an MIC90 of 4 μg/mL. Of all P. aeruginosa strains, 5.7% were resistant to six or more agents of nine antipseudomonal agents, a decrease compared to 8.7% in 2004. Against other glucose-non-fermentative Gram-negative bacteria, the activity of most antibacterial agents was similar to that in 2004.
AB - We determined MICs of antibacterial agents against 1280 clinical strains of aerobic Gram-negative bacteria (19 genus or species) isolated at 16 Japanese facilities in 2006. MICs were determined using mostly broth microdilution method and antibacterial activity was assessed. Strains producing extended-spectrum β-lactamases (ESBL) accounted for 3.7% of Escherichia coli, 2.7% of Klebsiella spp., and 11.4% of Proteus spp. Notably, 18.8% of Proteus mirabilis was found to produce ESBL higher than 16.7% in 2004. This result was higher extremely than other species. Among Haemophilus influenzae, only 1.2% produced β-lactamase and 62.8% that increased compared with 57.7% in 2004, were β-lactamase-negative ampicillin-resistant strains when classified by penicillin-binding protein 3 mutation. Although few antibacterial agents against Pseudomonas aeruginosa have potent activity, only three agents - doripenem, ciprofloxacin, and tobramycin - showed an MIC90 of 4 μg/mL. Of all P. aeruginosa strains, 5.7% were resistant to six or more agents of nine antipseudomonal agents, a decrease compared to 8.7% in 2004. Against other glucose-non-fermentative Gram-negative bacteria, the activity of most antibacterial agents was similar to that in 2004.
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M3 - Article
C2 - 21425597
AN - SCOPUS:79551593051
SN - 0368-2781
VL - 63
SP - 457
EP - 479
JO - The Journal of antibiotics. Ser. B
JF - The Journal of antibiotics. Ser. B
IS - 6
ER -
