Antinociceptive effects of intrathecal landiolol injection in a rat formalin pain model

Satoshi Mizobuchi, Yoshikazu Matsuoka, Norihiko Obata, Ryuji Kaku, Yoshitaro Itano, Naoto Tomotsuka, Arata Taniguchi, Hiroyuki Nishie, Hirotaka Kanzaki, Mamoru Ouchida, Kiyoshi Morita

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Perioperative beta-blocker administration has recently been recommended for patients undergoing cardiac or other surgery due to the beneficial cardiovascular effects of these agents. In addition, some studies have reported that perioperatively administered beta-blockers also have analgesic effects. In this study, to investigate the antinociceptive effects and the analgesic profile of landiolol, we examined the effects of intrathecal landiolol administration on nociceptive pain behavior and c-fos mRNA expression (a neural marker of pain) in the spinal cord using a rat formalin model. We found that pain-related behavior was inhibited by intrathecal landiolol administration. Moreover, the increase in c-fos mRNA expression on the formalin-injected side was less pronounced in rats administered landiolol than in saline administered controls. Thus, intrathecal administration of landiolol exhibited antinociceptive effects. Further investigation of the antinociceptive mechanism of landiolol is required.

Original languageEnglish
Pages (from-to)285-289
Number of pages5
JournalActa medica Okayama
Issue number3
Publication statusPublished - 2012


  • Beta-blocker
  • C-fos
  • Formalin
  • Landiolol
  • Pain behavior

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology


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